ID   EKI_NEMVE               Reviewed;         349 AA.
AC   A7SK27;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Probable ethanolamine kinase;
DE            EC=2.7.1.82;
GN   Name=etnk; ORFNames=v1g190677;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Highly specific for ethanolamine phosphorylation. May be a
CC       rate-controlling step in phosphatidylethanolamine biosynthesis (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + ethanolamine = ADP + H(+) + phosphoethanolamine;
CC         Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216;
CC         EC=2.7.1.82;
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC       biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC       {ECO:0000305}.
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DR   EMBL; DS469683; EDO35939.1; -; Genomic_DNA.
DR   RefSeq; XP_001628002.1; XM_001627952.1.
DR   AlphaFoldDB; A7SK27; -.
DR   SMR; A7SK27; -.
DR   STRING; 45351.EDO35939; -.
DR   EnsemblMetazoa; EDO35939; EDO35939; NEMVEDRAFT_v1g190677.
DR   GeneID; 5507359; -.
DR   KEGG; nve:5507359; -.
DR   eggNOG; KOG4720; Eukaryota.
DR   HOGENOM; CLU_012712_1_0_1; -.
DR   InParanoid; A7SK27; -.
DR   OMA; FKMKPEA; -.
DR   OrthoDB; 349250at2759; -.
DR   PhylomeDB; A7SK27; -.
DR   UniPathway; UPA00558; UER00741.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004305; F:ethanolamine kinase activity; IBA:GO_Central.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Lipid biosynthesis; Lipid metabolism;
KW   Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..349
FT                   /note="Probable ethanolamine kinase"
FT                   /id="PRO_0000332723"
SQ   SEQUENCE   349 AA;  40236 MW;  DFBB03B234542756 CRC64;
     MSVPHIQHRL DPDDPNTSIK AVIKEIKPEL DPENLEFFEF TEGISNKLVG CRPTGGSDQE
     ILLFRIYGNK TELFIDRKKE IATYSILNPL GYAPPVYATF ENGFCYGFMV GSVMCPKTVC
     DPHISSLIAK HVADLHAIKL QEENPQPSWY KAILHFFSII PDKFPDAAKE NRFKEVLASK
     AYLLEEVKLL KSKLDKLESA IVFAHNDLLC KNIIYNKDKD SVCTIDFEYA NPNPIAYDIA
     NHFCEYAGVD EVDYSLYPQK DHQVKFLESY LKRAMELQGE KDVNPSSREI EKLYVHVNQF
     ALAAHFFWGV WGLVQAHYSE IDFDFLEYAI TRLNEYYLRK EKFLSLTCE