ID   EL2A_HORSE              Reviewed;          85 AA.
AC   P37357;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   12-AUG-2020, entry version 81.
DE   RecName: Full=Neutrophil elastase 2A;
DE            EC=3.4.21.-;
DE   AltName: Full=Proteinase 2A;
DE   Flags: Fragments;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Neutrophil;
RX   PubMed=7516152; DOI=10.1042/bj3000401;
RA   Dubin A., Potempa J., Travis J.;
RT   "Structural and functional characterization of elastases from horse
RT   neutrophils.";
RL   Biochem. J. 300:401-406(1994).
CC   -!- FUNCTION: May be involved in the degradation of connective tissue in
CC       chronic lung disease.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Elastase subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
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DR   PIR; S44461; S44461.
DR   MEROPS; S01.131; -.
DR   PeptideAtlas; P37357; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006909; P:phagocytosis; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 2.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Protease; Reference proteome;
KW   Serine protease.
FT   CHAIN           1..85
FT                   /note="Neutrophil elastase 2A"
FT                   /id="PRO_0000088680"
FT   DOMAIN          1..85
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   ACT_SITE        67
FT                   /note="Charge relay system"
FT   NON_CONS        34..35
FT                   /evidence="ECO:0000305"
FT   NON_CONS        59..60
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   85 AA;  8893 MW;  0ABE7D44A1B90E26 CRC64;
     IVGGRAAEPH SRPYMVSLQI RGNPGSHFCG GTLIMGWGRL GTREPLPXVL QELNVTVVTA
     GICFGDSGGP LICNGVAQGV FSFVR