EL2B_HORSE
ID EL2B_HORSE Reviewed; 73 AA.
AC P37358;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Neutrophil elastase 2B;
DE EC=3.4.21.-;
DE AltName: Full=Proteinase 2B;
DE Flags: Fragments;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Neutrophil;
RX PubMed=7516152; DOI=10.1042/bj3000401;
RA Dubin A., Potempa J., Travis J.;
RT "Structural and functional characterization of elastases from horse
RT neutrophils.";
RL Biochem. J. 300:401-406(1994).
CC -!- FUNCTION: May be involved in the degradation of connective tissue in
CC chronic lung disease.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. Elastase subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00274}.
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DR PIR; S44462; S44462.
DR AlphaFoldDB; P37358; -.
DR SMR; P37358; -.
DR MEROPS; S01.131; -.
DR Proteomes; UP000002281; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0002438; P:acute inflammatory response to antigenic stimulus; IBA:GO_Central.
DR GO; GO:0006909; P:phagocytosis; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR Gene3D; 2.40.10.10; -; 1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001254; Trypsin_dom.
DR Pfam; PF00089; Trypsin; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Hydrolase; Protease; Reference proteome;
KW Serine protease.
FT CHAIN 1..73
FT /note="Neutrophil elastase 2B"
FT /id="PRO_0000088681"
FT DOMAIN 1..73
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT ACT_SITE 64
FT /note="Charge relay system"
FT NON_CONS 31..32
FT /evidence="ECO:0000305"
FT NON_CONS 56..57
FT /evidence="ECO:0000305"
SQ SEQUENCE 73 AA; 7615 MW; AFFB0B330DB69041 CRC64;
IVGGRPARPH AWPFMASLQR RGGHFCGATL IMGWGQLGTN RPLPSVLQEL NVTVVTAGIC
FGDSGGPLVC NGL