ID   ELAV2_PONAB             Reviewed;         359 AA.
AC   Q5R9Z6;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=ELAV-like protein 2;
GN   Name=ELAVL2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that binds to the 3' untranslated region
CC       (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA
CC       motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the
CC       ID 3'UTR (By similarity). {ECO:0000250|UniProtKB:Q60899}.
CC   -!- SUBUNIT: Interacts with IGF2BP1 (By similarity). Interacts with MAP1B
CC       light chain LC1 (By similarity). {ECO:0000250|UniProtKB:Q12926,
CC       ECO:0000250|UniProtKB:Q60899}.
CC   -!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000305}.
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DR   EMBL; CR859234; CAH91414.1; -; mRNA.
DR   RefSeq; NP_001127414.1; NM_001133942.1.
DR   RefSeq; XP_009242651.1; XM_009244376.1.
DR   RefSeq; XP_009242652.1; XM_009244377.1.
DR   AlphaFoldDB; Q5R9Z6; -.
DR   SMR; Q5R9Z6; -.
DR   STRING; 9601.ENSPPYP00000021474; -.
DR   Ensembl; ENSPPYT00000059224; ENSPPYP00000030326; ENSPPYG00000019166.
DR   GeneID; 100174484; -.
DR   GeneID; 100189792; -.
DR   CTD; 1993; -.
DR   eggNOG; KOG0145; Eukaryota.
DR   GeneTree; ENSGT00940000156823; -.
DR   HOGENOM; CLU_026186_2_2_1; -.
DR   InParanoid; Q5R9Z6; -.
DR   Proteomes; UP000001595; Chromosome 9.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd12650; RRM1_Hu; 1.
DR   CDD; cd12775; RRM2_HuB; 1.
DR   CDD; cd12654; RRM3_HuB; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR006548; ELAD_HU_SF.
DR   InterPro; IPR034775; ELAV/Hu_RRM1.
DR   InterPro; IPR034999; HuB_RRM2.
DR   InterPro; IPR034914; HuB_RRM3.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..359
FT                   /note="ELAV-like protein 2"
FT                   /id="PRO_0000232767"
FT   DOMAIN          39..117
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          125..205
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          276..354
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         221
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q12926"
SQ   SEQUENCE   359 AA;  39504 MW;  15E87088FC546DDC CRC64;
     METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM TQEELKSLFG
     SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA
     SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGISRGVGF IRFDKRIEAE
     EAIKGLNGQK PPGATEPITV KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD
     NLLNMAYGVK RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG
     AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTNKTHKA