ID   ELAV2_RAT               Reviewed;         359 AA.
AC   Q8CH84;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=ELAV-like protein 2;
DE   AltName: Full=Hu-antigen B;
DE            Short=HuB;
GN   Name=Elavl2; Synonyms=Hub;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RA   Mori R., Suda H., Suzuki G., Wakizono T., Kuwahara T., Suda S., Nibuya M.,
RA   Nomura S.;
RT   "Cloning of rat HuB transcript with poly-A 3' tail.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: RNA-binding protein that binds to the 3' untranslated region
CC       (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA
CC       motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the
CC       ID 3'UTR (By similarity). {ECO:0000250|UniProtKB:Q60899}.
CC   -!- SUBUNIT: Interacts with IGF2BP1 (By similarity). Interacts with MAP1B
CC       light chain LC1 (By similarity). {ECO:0000250|UniProtKB:Q12926,
CC       ECO:0000250|UniProtKB:Q60899}.
CC   -!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000305}.
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DR   EMBL; AB098713; BAC53775.1; -; mRNA.
DR   AlphaFoldDB; Q8CH84; -.
DR   SMR; Q8CH84; -.
DR   IntAct; Q8CH84; 1.
DR   MINT; Q8CH84; -.
DR   STRING; 10116.ENSRNOP00000009034; -.
DR   iPTMnet; Q8CH84; -.
DR   PhosphoSitePlus; Q8CH84; -.
DR   jPOST; Q8CH84; -.
DR   PaxDb; Q8CH84; -.
DR   PRIDE; Q8CH84; -.
DR   UCSC; RGD:628611; rat.
DR   RGD; 628611; Elavl2.
DR   eggNOG; KOG0145; Eukaryota.
DR   InParanoid; Q8CH84; -.
DR   PhylomeDB; Q8CH84; -.
DR   Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q8CH84; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; ISO:RGD.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; ISO:RGD.
DR   CDD; cd12650; RRM1_Hu; 1.
DR   CDD; cd12775; RRM2_HuB; 1.
DR   CDD; cd12654; RRM3_HuB; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR006548; ELAD_HU_SF.
DR   InterPro; IPR034775; ELAV/Hu_RRM1.
DR   InterPro; IPR034999; HuB_RRM2.
DR   InterPro; IPR034914; HuB_RRM3.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
DR   PROSITE; PS50102; RRM; 3.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..359
FT                   /note="ELAV-like protein 2"
FT                   /id="PRO_0000232768"
FT   DOMAIN          39..117
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          125..205
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          276..354
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         221
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   359 AA;  39506 MW;  1F07FBCA37DEFE72 CRC64;
     METQLSNGPT CNNTANGPTT VNNNCSSPVD SGNTEDSKTN LIDNYLPQNM TQEELKSLFG
     SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA
     SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGISRGVGF IRFDKRIEAE
     EAIKGLNGQK PPGATEPITV KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD
     NLLNMAYGVK RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG
     AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTNKTHKA