ELAV2_XENTR
ID ELAV2_XENTR Reviewed; 375 AA.
AC Q28GD4; A0JPB3;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 2.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=ELAV-like protein 2;
DE AltName: Full=Protein ElrB {ECO:0000250|UniProtKB:Q91903};
GN Name=elavl2 {ECO:0000312|EMBL:CAJ82281.1};
GN Synonyms=elrB {ECO:0000250|UniProtKB:Q91903}; ORFNames=TEgg126j06.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAJ82281.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Egg {ECO:0000312|EMBL:CAJ82281.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:CAJ82281.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=N6 {ECO:0000312|EMBL:AAI27339.1};
RC TISSUE=Oviduct {ECO:0000312|EMBL:AAI27339.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds to poly-U elements and AU-rich elements (AREs) in the
CC 3'-UTR of target mRNAs. Required for the vegetal localization of vg1
CC mRNA. Probably required for nervous system development (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Part of a ribonucleoprotein (RNP) complex, at least composed
CC of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54,
CC ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes,
CC stau1/staufen. Binds RNA as a homooligomer (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q91903}.
CC Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q91903}. Note=Enriched at
CC the vegetal cortex in stage III and IV oocytes.
CC {ECO:0000250|UniProtKB:Q91903}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q28GD4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q28GD4-2; Sequence=VSP_038718;
CC -!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI27339.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR761432; CAJ82281.1; -; mRNA.
DR EMBL; BC127338; AAI27339.1; ALT_INIT; mRNA.
DR RefSeq; NP_001025498.3; NM_001030327.4. [Q28GD4-1]
DR RefSeq; XP_012819058.1; XM_012963604.2.
DR AlphaFoldDB; Q28GD4; -.
DR SMR; Q28GD4; -.
DR PaxDb; Q28GD4; -.
DR DNASU; 594913; -.
DR Ensembl; ENSXETT00000091618; ENSXETP00000076320; ENSXETG00000038617.
DR GeneID; 594913; -.
DR KEGG; xtr:594913; -.
DR CTD; 1993; -.
DR Xenbase; XB-GENE-491749; elavl2.
DR eggNOG; KOG0145; Eukaryota.
DR InParanoid; Q28GD4; -.
DR OrthoDB; 775799at2759; -.
DR Reactome; R-XTR-72163; mRNA Splicing - Major Pathway.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000038617; Expressed in brain and 8 other tissues.
DR ExpressionAtlas; Q28GD4; differential.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd12650; RRM1_Hu; 1.
DR CDD; cd12775; RRM2_HuB; 1.
DR CDD; cd12654; RRM3_HuB; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR006548; ELAD_HU_SF.
DR InterPro; IPR034775; ELAV/Hu_RRM1.
DR InterPro; IPR034999; HuB_RRM2.
DR InterPro; IPR034914; HuB_RRM3.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 3.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
DR PROSITE; PS50102; RRM; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Developmental protein; Reference proteome;
KW Repeat; Ribonucleoprotein; RNA-binding.
FT CHAIN 1..375
FT /note="ELAV-like protein 2"
FT /id="PRO_0000391372"
FT DOMAIN 67..145
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 153..233
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 292..370
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT VAR_SEQ 265
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_038718"
SQ SEQUENCE 375 AA; 41137 MW; 82C3387348F32890 CRC64;
MAVRLCDVAS LLRSGSWAAE PWTGQVIAAM ETQLSNGPTC NNTANCPNTI NNCSSPVESS
NTEDSKTNLI VNYLPQNMTQ EELKSLFGSI GEIESCKLVR DKITGQSLGY GFVNYIDPKD
AEKAINTLNG LRLQTKTIKV SYARPSSASI RDANLYVSGL PKTMTQKELE QLFSQYGRII
TSRILVDQVT GVSRGVGFIR FDKRIEAEEA IKGLNGQKPP GATEPITVKF ANNPSQKVNH
TILSQLYQSP NRRYPGPLAQ QAQRFSRFSP MTIDGMTSLA GINFPGHAGT GWCIFVYNLA
PDADESILWQ MFGPFGAVTN VKVIRDFNTN KCKGFGFVTM TNYDEAAMAI ASLNGYRLGD
RVLQVSFKTS KTHKA