ELAV3_XENLA
ID ELAV3_XENLA Reviewed; 348 AA.
AC Q91584; B7ZQD6;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=ELAV-like protein 3;
DE AltName: Full=Protein ElrC {ECO:0000312|EMBL:AAI69769.1};
GN Name=elavl3; Synonyms=elrC {ECO:0000312|EMBL:AAA96944.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAA96944.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Embryonic head {ECO:0000312|EMBL:AAA96944.1};
RX PubMed=7753842; DOI=10.1073/pnas.92.10.4557;
RA Good P.J.;
RT "A conserved family of elav-like genes in vertebrates.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:4557-4561(1995).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAI69769.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAI69769.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=10473128; DOI=10.1016/s0925-4773(99)00056-8;
RA Perron M., Furrer M.P., Wegnez M., Theodore L.;
RT "Xenopus elav-like genes are differentially expressed during
RT neurogenesis.";
RL Mech. Dev. 84:139-142(1999).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16112102; DOI=10.1016/j.ydbio.2005.06.033;
RA Logan M.A., Steele M.R., Van Raay T.J., Vetter M.L.;
RT "Identification of shared transcriptional targets for the proneural bHLH
RT factors Xath5 and XNeuroD.";
RL Dev. Biol. 285:570-583(2005).
RN [5] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15593335; DOI=10.1002/cne.20387;
RA Amato M.A., Boy S., Arnault E., Girard M., Della Puppa A., Sharif A.,
RA Perron M.;
RT "Comparison of the expression patterns of five neural RNA binding proteins
RT in the Xenopus retina.";
RL J. Comp. Neurol. 481:331-339(2005).
CC -!- FUNCTION: RNA-binding protein that binds to AU-rich element (ARE)
CC sequences of target mRNAs. May also bind poly-A tracts via RRM 3. May
CC be involved in neuronal differentiation and maintenance (By
CC similarity). {ECO:0000250|UniProtKB:Q60900}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:7753842};
CC IsoId=Q91584-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91584-2; Sequence=VSP_038719;
CC -!- TISSUE SPECIFICITY: Expression is neural-specific in both embryos and
CC adults. Expressed from neurula stage onwards in primary motor-,
CC inter- and sensory-neurons. Expressed in the closing neural tube and
CC motor neurons of stage 18 embryos, and primarily in the ventricular
CC zone and dorsal region of the tailbud and adult brain. Expressed from
CC stage 26 onwards in the differentiating ganglion cell layer of the
CC retina, extending to the inner nuclear layer at later stages.
CC {ECO:0000269|PubMed:10473128, ECO:0000269|PubMed:15593335,
CC ECO:0000269|PubMed:16112102, ECO:0000269|PubMed:7753842}.
CC -!- DEVELOPMENTAL STAGE: Expressed by late gastrula stage (stage 11).
CC {ECO:0000269|PubMed:10473128, ECO:0000269|PubMed:7753842}.
CC -!- INDUCTION: By bHLH transcription factors atoh7/ath5 and neurod1/neuroD.
CC {ECO:0000269|PubMed:16112102}.
CC -!- DOMAIN: RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in
CC target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).
CC {ECO:0000250|UniProtKB:Q60900}.
CC -!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000255}.
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DR EMBL; U17598; AAA96944.1; -; mRNA.
DR EMBL; BC169769; AAI69769.1; -; mRNA.
DR PIR; I51677; I51677.
DR RefSeq; NP_001084080.1; NM_001090611.1. [Q91584-1]
DR RefSeq; XP_018097510.1; XM_018242021.1. [Q91584-2]
DR AlphaFoldDB; Q91584; -.
DR SMR; Q91584; -.
DR GeneID; 399293; -.
DR KEGG; xla:399293; -.
DR CTD; 399293; -.
DR Xenbase; XB-GENE-866009; elavl3.L.
DR OrthoDB; 614259at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 399293; Expressed in brain and 5 other tissues.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd12650; RRM1_Hu; 1.
DR CDD; cd12655; RRM3_HuC; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR006548; ELAD_HU_SF.
DR InterPro; IPR034775; ELAV/Hu_RRM1.
DR InterPro; IPR034915; HuC_RRM3.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR Pfam; PF00076; RRM_1; 3.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 3.
DR SMART; SM00361; RRM_1; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
DR PROSITE; PS50102; RRM; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; Differentiation; Neurogenesis;
KW Reference proteome; Repeat; Ribonucleoprotein; RNA-binding.
FT CHAIN 1..348
FT /note="ELAV-like protein 3"
FT /id="PRO_0000391373"
FT DOMAIN 34..112
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 120..200
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 265..343
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT VAR_SEQ 233..239
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_038719"
SQ SEQUENCE 348 AA; 38143 MW; 9C0FF1595AD631D5 CRC64;
MVTIISTMET QANNGPGCVG ILNGTNGEAD DSKTNLIVNY LPQNMTQEEF KSLFGSIGEI
ESCKLVRDKI TGQSLGYGFV NYVDPNDADK AINTLNGLKL QTKTIKVSYA RPSSASIRDA
NLYVSSLPKT MNQKEMEQLF SQYGRIITSR ILVDQVTGVS RGVGFIRFDK RIEAEEAIKG
LNGQKPLGAS EPITVKFANN PSQKTGQALL THLYQTTARR YTGPLHHQTQ RFSPLSILPR
FSPITIDSVT NLAGVSLTGP TTAGWCIFVY NLSPEADESV LWQLFGPFGA VTNVKVIRDF
TTNKCKGFGF VTMTNYDEAA MAIASLNGYR LGDRVLQVSF KTSKQHKA
