ID   ELAV3_XENTR             Reviewed;         343 AA.
AC   Q28FX0; A4IIS4;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=ELAV-like protein 3 {ECO:0000250|UniProtKB:Q60900};
DE   AltName: Full=Protein ElrC {ECO:0000250|UniProtKB:Q91584};
GN   Name=elavl3 {ECO:0000312|EMBL:CAJ83874.1};
GN   Synonyms=elrC {ECO:0000250|UniProtKB:Q91584}; ORFNames=TGas116i13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAJ83874.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83874.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305, ECO:0000312|EMBL:CAJ83874.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain {ECO:0000312|EMBL:AAI36135.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that binds to AU-rich sequences (AREs) of
CC       target mRNAs. May also bind poly-A tracts via RRM 3. May be involved in
CC       neuronal differentiation and maintenance (By similarity).
CC       {ECO:0000250|UniProtKB:Q60900}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q28FX0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q28FX0-2; Sequence=VSP_038720;
CC   -!- DOMAIN: RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in
CC       target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).
CC       {ECO:0000250|UniProtKB:Q60900}.
CC   -!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR761704; CAJ83874.1; -; mRNA.
DR   EMBL; BC136134; AAI36135.1; -; mRNA.
DR   RefSeq; NP_001025497.1; NM_001030326.2. [Q28FX0-1]
DR   RefSeq; XP_012808621.1; XM_012953167.2. [Q28FX0-2]
DR   AlphaFoldDB; Q28FX0; -.
DR   SMR; Q28FX0; -.
DR   STRING; 8364.ENSXETP00000019000; -.
DR   DNASU; 594912; -.
DR   GeneID; 594912; -.
DR   KEGG; xtr:594912; -.
DR   CTD; 1995; -.
DR   Xenbase; XB-GENE-490864; elavl3.
DR   eggNOG; KOG0145; Eukaryota.
DR   InParanoid; Q28FX0; -.
DR   OrthoDB; 614259at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q28FX0; baseline and differential.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   CDD; cd12650; RRM1_Hu; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR006548; ELAD_HU_SF.
DR   InterPro; IPR034775; ELAV/Hu_RRM1.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR003954; RRM_dom_euk.
DR   Pfam; PF00076; RRM_1; 3.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 3.
DR   SMART; SM00361; RRM_1; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; Differentiation; Neurogenesis;
KW   Reference proteome; Repeat; Ribonucleoprotein; RNA-binding.
FT   CHAIN           1..343
FT                   /note="ELAV-like protein 3"
FT                   /id="PRO_0000391374"
FT   DOMAIN          35..113
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          121..202
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          260..338
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   VAR_SEQ         160
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_038720"
SQ   SEQUENCE   343 AA;  37550 MW;  0E9F530914F911C7 CRC64;
     MVTQIISTME TQASNGPGSV GILNGTNGAA DDSKTNLIVN YLPQNMTQEE FKSLFGSIGE
     IESCKLVRDK ITGQSLGYGF VNYVDPNDAD KAINTLNGLK LQTKTIKVSY ARPSSASIRD
     ANLYVSSLPK TMNQKEMEQL FSQYGRIITS RILVDQVTGS VSRGVGFIRF DKRIEAEEAI
     KGLNGQKPLG ASEPITVKFA NNPSQKTGQA LLTHLYQTTA RRYTGPLHHQ TQRFRFSPIT
     IDSVTNLAGV SLTGPTTAGW CIFVYNLSPE ADESVLWQLF GPFGAVTNVK VIRDFTTNKC
     KGFGFVTMTN YDEAAMAIAS LNGYRLGDRV LQVSFKTSKQ HKA