ELAV4_XENLA
ID ELAV4_XENLA Reviewed; 400 AA.
AC Q7SZT7; Q4FZM7; Q7ZTQ4; Q91585; Q98TU5;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=ELAV-like protein 4 {ECO:0000250|UniProtKB:P26378};
DE AltName: Full=Protein ElrD {ECO:0000312|EMBL:AAH56021.1};
GN Name=elavl4; Synonyms=elrD {ECO:0000312|EMBL:AAH56021.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAA96945.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Tadpole brain {ECO:0000312|EMBL:AAA96945.1};
RX PubMed=7753842; DOI=10.1073/pnas.92.10.4557;
RA Good P.J.;
RT "A conserved family of elav-like genes in vertebrates.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:4557-4561(1995).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH56021.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 12-400 (ISOFORM 1).
RC TISSUE=Tadpole {ECO:0000312|EMBL:AAH99348.1}, and
RC Tail bud {ECO:0000312|EMBL:AAH56021.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAK01428.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8 (ISOFORM 2), AND ALTERNATIVE
RP SPLICING.
RX PubMed=11327714; DOI=10.1006/bbrc.2001.4812;
RA Nassar F., Wegnez M.;
RT "Characterization of two promoters of the Xenopus laevis elrD gene.";
RL Biochem. Biophys. Res. Commun. 283:392-398(2001).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=10473128; DOI=10.1016/s0925-4773(99)00056-8;
RA Perron M., Furrer M.P., Wegnez M., Theodore L.;
RT "Xenopus elav-like genes are differentially expressed during
RT neurogenesis.";
RL Mech. Dev. 84:139-142(1999).
RN [5] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15593335; DOI=10.1002/cne.20387;
RA Amato M.A., Boy S., Arnault E., Girard M., Della Puppa A., Sharif A.,
RA Perron M.;
RT "Comparison of the expression patterns of five neural RNA binding proteins
RT in the Xenopus retina.";
RL J. Comp. Neurol. 481:331-339(2005).
CC -!- FUNCTION: RNA-binding protein that is involved in the post-
CC transcriptional regulation of mRNAs (By similarity). Plays a role in
CC the regulation of mRNA stability, alternative splicing and translation
CC (By similarity). Binds to AU-rich element (ARE) sequences in the 3'
CC untranslated region (3'UTR) of target mRNAs (By similarity). Mainly
CC play a role in neuron-specific RNA processing (By similarity).
CC {ECO:0000250|UniProtKB:O09032, ECO:0000250|UniProtKB:P26378,
CC ECO:0000250|UniProtKB:Q61701}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O09032}.
CC Perikaryon {ECO:0000250|UniProtKB:Q61701}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q61701}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q61701}. Cell projection, growth cone
CC {ECO:0000250|UniProtKB:Q61701}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=2 {ECO:0000269|PubMed:11327714}; Synonyms=ELRD2
CC {ECO:0000269|PubMed:11327714};
CC IsoId=Q7SZT7-1; Sequence=Displayed;
CC Name=1 {ECO:0000269|PubMed:7753842}; Synonyms=ELRD1
CC {ECO:0000269|PubMed:11327714};
CC IsoId=Q7SZT7-2; Sequence=VSP_053191, VSP_053192;
CC Name=3;
CC IsoId=Q7SZT7-3; Sequence=VSP_053191;
CC -!- TISSUE SPECIFICITY: Expression is neural-specific. In the retina,
CC expressed in the ganglion cell layer from stage 28 onwards and in
CC amacrine cells from stage 35 onwards. Expressed in the tailbud and
CC adult brain; in tailbuds, expression is predominant in the cortical
CC plate. {ECO:0000269|PubMed:10473128, ECO:0000269|PubMed:15593335,
CC ECO:0000269|PubMed:7753842}.
CC -!- DEVELOPMENTAL STAGE: Expressed after stage 19 (late neurula).
CC {ECO:0000269|PubMed:7753842}.
CC -!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U17599; AAA96945.1; -; mRNA.
DR EMBL; BC043735; AAH43735.1; -; mRNA.
DR EMBL; BC056021; AAH56021.1; -; mRNA.
DR EMBL; BC099348; AAH99348.1; -; mRNA.
DR EMBL; AF329448; AAK01428.1; -; Genomic_DNA.
DR PIR; I51678; I51678.
DR RefSeq; NP_001080909.1; NM_001087440.1. [Q7SZT7-1]
DR RefSeq; XP_018111995.1; XM_018256506.1. [Q7SZT7-3]
DR RefSeq; XP_018111999.1; XM_018256510.1. [Q7SZT7-2]
DR AlphaFoldDB; Q7SZT7; -.
DR SMR; Q7SZT7; -.
DR DNASU; 386602; -.
DR GeneID; 386602; -.
DR KEGG; xla:386602; -.
DR CTD; 386602; -.
DR Xenbase; XB-GENE-948214; elavl4.L.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 386602; Expressed in brain and 7 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd12650; RRM1_Hu; 1.
DR CDD; cd12656; RRM3_HuD; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR006548; ELAD_HU_SF.
DR InterPro; IPR034775; ELAV/Hu_RRM1.
DR InterPro; IPR034918; HuD_RRM3.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 4.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
DR PROSITE; PS50102; RRM; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cytoplasm; Developmental protein;
KW Reference proteome; Repeat; Ribonucleoprotein; RNA-binding.
FT CHAIN 1..400
FT /note="ELAV-like protein 4"
FT /id="PRO_0000391375"
FT DOMAIN 51..158
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 166..246
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 317..395
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 12..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..7
FT /note="MEWNGLK -> MV (in isoform 1 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:7753842, ECO:0000303|Ref.2"
FT /id="VSP_053191"
FT VAR_SEQ 89..117
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:7753842, ECO:0000303|Ref.2"
FT /id="VSP_053192"
SQ SEQUENCE 400 AA; 44216 MW; 32B4F265B57DDAB4 CRC64;
MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNSRNCPSPM QTGAATDDSK TNLIVNYLPQ
NMTQEEFRSL FGSIGEIESC KLVRDKITGT QFEENFKDLA TGTKWKPLTE EGPIFGKGQS
LGYGFVNYID PKDAEKAINT LNGLRLQTKT IKVSYARPSS ASIRDANLYV SGLPKTMTQK
ELEQLFSQYG RIITSRILVD QVTGVSRGVG FIRFDKRIEA EEAIKGLNGQ KPSGAAEPIT
VKFANNPSQK TSQALLSQLY QSPNRRYPGP LHHQAQRFRL DNLLNMAYGV KRFSPITIDG
MTSLVGMNIP GHTGTGWCIF VYNLSPDSDE SVLWQLFGPF GAVNNVKVIR DFNTNKCKGF
GFVTMTNYDE AAMAIASLNG YRLGDRVLQV SFKTNKTHKS
