ID   ELAV4_XENTR             Reviewed;         400 AA.
AC   A4QNI8;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=ELAV-like protein 4 {ECO:0000250|UniProtKB:P26378};
DE   AltName: Full=Protein ElrD {ECO:0000250|UniProtKB:Q7SZT7};
GN   Name=elavl4; Synonyms=elrD {ECO:0000250|UniProtKB:Q7SZT7};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI35737.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole {ECO:0000312|EMBL:AAI35737.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that is involved in the post-
CC       transcriptional regulation of mRNAs (By similarity). Plays a role in
CC       the regulation of mRNA stability, alternative splicing and translation
CC       (By similarity). Binds to AU-rich element (ARE) sequences in the 3'
CC       untranslated region (3'UTR) of target mRNAs (By similarity). Mainly
CC       plays a role in neuron-specific RNA processing (By similarity).
CC       {ECO:0000250|UniProtKB:P26378, ECO:0000250|UniProtKB:Q61701}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O09032}.
CC       Perikaryon {ECO:0000250|UniProtKB:Q61701}. Cell projection, axon
CC       {ECO:0000250|UniProtKB:Q61701}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q61701}. Cell projection, growth cone
CC       {ECO:0000250|UniProtKB:Q61701}.
CC   -!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000255}.
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DR   EMBL; BC135736; AAI35737.1; -; mRNA.
DR   RefSeq; NP_001096525.1; NM_001103055.1.
DR   AlphaFoldDB; A4QNI8; -.
DR   SMR; A4QNI8; -.
DR   STRING; 8364.ENSXETP00000007497; -.
DR   PaxDb; A4QNI8; -.
DR   DNASU; 100125165; -.
DR   Ensembl; ENSXETT00000018998; ENSXETP00000018998; ENSXETG00000008680.
DR   GeneID; 100125165; -.
DR   KEGG; xtr:100125165; -.
DR   CTD; 1996; -.
DR   Xenbase; XB-GENE-948210; elavl4.
DR   eggNOG; KOG0145; Eukaryota.
DR   InParanoid; A4QNI8; -.
DR   OrthoDB; 614259at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008680; Expressed in brain and 5 other tissues.
DR   ExpressionAtlas; A4QNI8; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd12650; RRM1_Hu; 1.
DR   CDD; cd12656; RRM3_HuD; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR006548; ELAD_HU_SF.
DR   InterPro; IPR034775; ELAV/Hu_RRM1.
DR   InterPro; IPR034918; HuD_RRM3.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 4.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Developmental protein; Reference proteome;
KW   Repeat; Ribonucleoprotein; RNA-binding.
FT   CHAIN           1..400
FT                   /note="ELAV-like protein 4"
FT                   /id="PRO_0000391376"
FT   DOMAIN          51..158
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          166..246
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          317..395
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          12..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   400 AA;  44239 MW;  6116611ED9FAEA6F CRC64;
     MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNSRNCPSPM QTGAATDDSK TNLIVNYLPQ
     NMTQEEFRSL FGSIGEIESC KLVRDKITGT QFEEHFKDLA TGTKWKPLTE EGPIFGKGQS
     LGYGFVNYID PKDAEKAINT LNGLRLQTKT IKVSYARPSS ASIRDANLYV SGLPKTMTQK
     ELEQLFSQYG RIITSRILVD QVTGVSRGVG FIRFDKRIEA EEAIKGLNGQ KPSGAAEPIT
     VKFANNPSQK TSQALLSQLY QSPNRRYPGP LHHQAQRFRL DNLLNMAYGV KRFSPITIDG
     MTSLVGMNIP GHTGTGWCIF VYNLSPDSDE SVLWQLFGPF GAVNNVKVIR DFNTNKCKGF
     GFVTMTNYDE AAMAIASLNG YRLGDRVLQV SFKTNKTHKS