ELAV_DROME
ID ELAV_DROME Reviewed; 483 AA.
AC P16914; Q7K7L9; Q9V3F6;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 193.
DE RecName: Full=Protein elav;
DE AltName: Full=Embryonic lethal abnormal visual protein;
GN Name=elav; ORFNames=CG4262;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND FUNCTION.
RC STRAIN=Canton-S;
RX PubMed=3144044; DOI=10.1126/science.3144044;
RA Robinow S., Campos A.R., Yao K.-M., White K.;
RT "The elav gene product of Drosophila, required in neurons, has three RNP
RT consensus motifs.";
RL Science 242:1570-1572(1988).
RN [2]
RP ERRATUM OF PUBMED:3144044.
RA Robinow S., Campos A.R., Yao K.-M., White K.;
RL Science 243:12-12(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Required for the proper development and maintenance of
CC neurons presumably by affecting RNA metabolism.
CC {ECO:0000269|PubMed:3144044}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=P16914-1; Sequence=Displayed;
CC Name=B;
CC IsoId=P16914-2; Sequence=VSP_036582;
CC -!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000305}.
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DR EMBL; M21152; AAA28506.1; -; mRNA.
DR EMBL; AE014298; AAF45517.2; -; Genomic_DNA.
DR EMBL; AE014298; ACL82875.1; -; Genomic_DNA.
DR EMBL; AE014298; AAX52472.1; -; Genomic_DNA.
DR EMBL; AL022139; CAA18091.1; -; Genomic_DNA.
DR EMBL; AL022139; CAB37430.1; -; Genomic_DNA.
DR EMBL; AY051822; AAK93246.1; -; mRNA.
DR PIR; A33130; A33130.
DR RefSeq; NP_001014713.1; NM_001014713.4. [P16914-2]
DR RefSeq; NP_001138142.1; NM_001144670.2. [P16914-2]
DR RefSeq; NP_001245447.1; NM_001258518.3. [P16914-1]
DR RefSeq; NP_525033.1; NM_080294.5. [P16914-1]
DR AlphaFoldDB; P16914; -.
DR SMR; P16914; -.
DR BioGRID; 57569; 21.
DR DIP; DIP-23700N; -.
DR IntAct; P16914; 3.
DR STRING; 7227.FBpp0298002; -.
DR PaxDb; P16914; -.
DR DNASU; 31000; -.
DR EnsemblMetazoa; FBtr0070091; FBpp0070086; FBgn0260400. [P16914-1]
DR EnsemblMetazoa; FBtr0100254; FBpp0099643; FBgn0260400. [P16914-2]
DR EnsemblMetazoa; FBtr0114366; FBpp0112915; FBgn0260400. [P16914-2]
DR EnsemblMetazoa; FBtr0307173; FBpp0298002; FBgn0260400. [P16914-1]
DR GeneID; 31000; -.
DR KEGG; dme:Dmel_CG4262; -.
DR UCSC; CG4262-RB; d. melanogaster.
DR CTD; 31000; -.
DR FlyBase; FBgn0260400; elav.
DR VEuPathDB; VectorBase:FBgn0260400; -.
DR eggNOG; KOG0145; Eukaryota.
DR InParanoid; P16914; -.
DR PhylomeDB; P16914; -.
DR Reactome; R-DME-450520; HuR (ELAVL1) binds and stabilizes mRNA.
DR Reactome; R-DME-72163; mRNA Splicing - Major Pathway.
DR BioGRID-ORCS; 31000; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 31000; -.
DR PRO; PR:P16914; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0260400; Expressed in brain and 21 other tissues.
DR ExpressionAtlas; P16914; baseline and differential.
DR Genevisible; P16914; DM.
DR GO; GO:0015030; C:Cajal body; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR GO; GO:0003729; F:mRNA binding; ISS:FlyBase.
DR GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; NAS:UniProtKB.
DR GO; GO:0008266; F:poly(U) RNA binding; IDA:FlyBase.
DR GO; GO:0003723; F:RNA binding; IDA:FlyBase.
DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; NAS:UniProtKB.
DR GO; GO:0007281; P:germ cell development; NAS:UniProtKB.
DR GO; GO:0031441; P:negative regulation of mRNA 3'-end processing; IDA:FlyBase.
DR GO; GO:0007319; P:negative regulation of oskar mRNA translation; NAS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; NAS:FlyBase.
DR CDD; cd12650; RRM1_Hu; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR006548; ELAD_HU_SF.
DR InterPro; IPR034775; ELAV/Hu_RRM1.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 4.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
DR PROSITE; PS50102; RRM; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..483
FT /note="Protein elav"
FT /id="PRO_0000081575"
FT DOMAIN 149..240
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 248..329
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 402..480
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 120..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..4
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_036582"
SQ SEQUENCE 483 AA; 50817 MW; E57336106310810B CRC64;
MDFIMANTGA GGGVDTQAQL MQSAAAAAAV AATNAAAAPV QNAAAVAAAA QLQQQQVQQA
ILQVQQQQTQ QAVAAAAAAV TQQLQQQQQA VVAQQAVVQQ QQQQAAAVVQ QAAVQQAVVP
QPQQAQPNTN GNAGSGSQNG SNGSTETRTN LIVNYLPQTM TEDEIRSLFS SVGEIESVKL
IRDKSQVYID PLNPQAPSKG QSLGYGFVNY VRPQDAEQAV NVLNGLRLQN KTIKVSFARP
SSDAIKGANL YVSGLPKTMT QQELEAIFAP FGAIITSRIL QNAGNDTQTK GVGFIRFDKR
EEATRAIIAL NGTTPSSCTD PIVVKFSNTP GSTSKIIQPQ LPAFLNPQLV RRIGGAMHTP
VNKGLARFSP MAGDMLDVML PNGLGAAAAA ATTLASGPGG AYPIFIYNLA PETEEAALWQ
LFGPFGAVQS VKIVKDPTTN QCKGYGFVSM TNYDEAAMAI RALNGYTMGN RVLQVSFKTN
KAK
