ID   ELAV_DROVI              Reviewed;         519 AA.
AC   P23241;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Protein elav;
DE   AltName: Full=Embryonic lethal abnormal visual protein;
GN   Name=elav;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1903840; DOI=10.1128/mcb.11.6.2994-3000.1991;
RA   Yao K.-M., White K.;
RT   "Organizational analysis of elav gene and functional analysis of ELAV
RT   protein of Drosophila melanogaster and Drosophila virilis.";
RL   Mol. Cell. Biol. 11:2994-3000(1991).
CC   -!- FUNCTION: Probably involved in the RNA metabolism of neurons.
CC   -!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000305}.
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DR   EMBL; M61748; AAA28505.1; -; Genomic_DNA.
DR   PIR; A40252; A40252.
DR   AlphaFoldDB; P23241; -.
DR   SMR; P23241; -.
DR   STRING; 7244.FBpp0229142; -.
DR   EnsemblMetazoa; FBtr0440294; FBpp0396903; FBgn0013110.
DR   eggNOG; KOG0145; Eukaryota.
DR   OrthoDB; 614259at2759; -.
DR   GO; GO:0015030; C:Cajal body; IEA:EnsemblMetazoa.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0008266; F:poly(U) RNA binding; IEA:EnsemblMetazoa.
DR   GO; GO:0007417; P:central nervous system development; IEA:EnsemblMetazoa.
DR   GO; GO:0031441; P:negative regulation of mRNA 3'-end processing; IEA:EnsemblMetazoa.
DR   CDD; cd12650; RRM1_Hu; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR006548; ELAD_HU_SF.
DR   InterPro; IPR034775; ELAV/Hu_RRM1.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 4.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
DR   PROSITE; PS50102; RRM; 3.
PE   3: Inferred from homology;
KW   Repeat; RNA-binding.
FT   CHAIN           1..519
FT                   /note="Protein elav"
FT                   /id="PRO_0000081576"
FT   DOMAIN          185..276
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          284..365
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          438..516
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   519 AA;  55822 MW;  B01AF1C0D601B0D9 CRC64;
     MDFMMANTGA TGLDTQAQLM QSAAAAAAVA ATNAAAPVQN AAAVAAAAQL QQQQQQVQQA
     ILQVQQQQTQ QAVAAAAAAV TQQLQQQQQA VVQQAVVQQQ QQQQQQQQQQ QVVQQQQVQQ
     VQQAVVAVQQ QQQQQQQQQQ QQQVVQQQQQ QVVQQQVQQQ VQQANTNGNS GGAQNGSNGS
     TETRTNLIVN YLPQTMTEDE IRSLFSSVGE IESVKLIRDK SQVYIDPLNP QAPSKGQSLG
     YGFVNYVRPQ DAEQAVNVLN GLRLQNKTIK VSFARPSSDA IKGANLYVSG LPKTMTQQEL
     EAIFAPFGAI ITSRILQNAG NDTQTKGVGF IRFDKREEAT RAIIALNGTT PSSCTDPIVV
     KFSNTPGSTS KIIQPQLPAF LNPQLVRRIG GAMHTPVNKG LARFSPMAGD MLDVMLPNGL
     GAAAAAATTL ASGPGGAYPI FIYNLAPETE EAALWQLFGP FGAVQSVKIV KDPTTNQCKG
     YGFVSMTNYD EAAMAIRALN GYTMGNRVLQ VSFKTNKAK