ID   ELBH_ECOH1              Reviewed;         124 AA.
AC   D0Z6T1; P13811;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Heat-labile enterotoxin B chain;
DE   AltName: Full=LT-B, human;
DE   AltName: Full=LTH-B;
DE   Flags: Precursor;
GN   Name=eltB; Synonyms=ltpB; OrderedLocusNames=ETEC_p666_0650;
OS   Escherichia coli O78:H11 (strain H10407 / ETEC).
OG   Plasmid pEntH10407, and Plasmid p666.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316401;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H10407 / ETEC;
RX   PubMed=6759877; DOI=10.1007/bf00332701;
RA   Yamamoto T., Tamura T.A., Yokota T., Takano T.;
RT   "Overlapping genes in the heat-labile enterotoxin operon originating from
RT   Escherichia coli human strain.";
RL   Mol. Gen. Genet. 188:356-359(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H10407 / ETEC;
RX   PubMed=8486242; DOI=10.1111/j.1574-6968.1993.tb06092.x;
RA   Inoue T., Tsuji T., Koto M., Imamura S., Miyama A.;
RT   "Amino acid sequence of heat-labile enterotoxin from chicken
RT   enterotoxigenic Escherichia coli is identical to that of human strain H
RT   10407.";
RL   FEMS Microbiol. Lett. 108:157-161(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H10407 / ETEC; PLASMID=pEntH10407;
RX   PubMed=19767599; DOI=10.1093/dnares/dsp015;
RA   Ochi S., Shimizu T., Ohtani K., Ichinose Y., Arimitsu H., Tsukamoto K.,
RA   Kato M., Tsuji T.;
RT   "Nucleotide sequence analysis of the enterotoxigenic Escherichia coli Ent
RT   plasmid.";
RL   DNA Res. 16:299-309(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H10407 / ETEC; PLASMID=p666;
RX   PubMed=20802035; DOI=10.1128/jb.00710-10;
RA   Crossman L.C., Chaudhuri R.R., Beatson S.A., Wells T.J., Desvaux M.,
RA   Cunningham A.F., Petty N.K., Mahon V., Brinkley C., Hobman J.L.,
RA   Savarino S.J., Turner S.M., Pallen M.J., Penn C.W., Parkhill J.,
RA   Turner A.K., Johnson T.J., Thomson N.R., Smith S.G., Henderson I.R.;
RT   "A commensal gone bad: complete genome sequence of the prototypical
RT   enterotoxigenic Escherichia coli strain H10407.";
RL   J. Bacteriol. 192:5822-5831(2010).
CC   -!- FUNCTION: The biological activity of the toxin is produced by the A
CC       chain, which activates intracellular adenyl cyclase. {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of one A chain and of five B chains.
CC       {ECO:0000250}.
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DR   EMBL; J01646; AAB02982.1; -; Genomic_DNA.
DR   EMBL; S60731; AAC60441.1; -; Genomic_DNA.
DR   EMBL; AP010910; BAI49222.1; -; Genomic_DNA.
DR   EMBL; FN649417; CBJ04425.1; -; Genomic_DNA.
DR   PIR; A01820; QLECB.
DR   RefSeq; WP_012846869.1; NC_017722.1.
DR   RefSeq; YP_003293996.1; NC_013507.1.
DR   AlphaFoldDB; D0Z6T1; -.
DR   SMR; D0Z6T1; -.
DR   TCDB; 1.C.72.4.1; the pertussis toxin (ptx) family.
DR   EnsemblBacteria; CBJ04425; CBJ04425; ETEC_p666_0650.
DR   KEGG; elh:ETEC_p666_0650; -.
DR   HOGENOM; CLU_2002942_0_0_6; -.
DR   OMA; HIDSQKK; -.
DR   Proteomes; UP000006877; Plasmid p666.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR001835; Enterotoxin_B.
DR   Pfam; PF01376; Enterotoxin_b; 1.
DR   PRINTS; PR00772; ENTEROTOXINB.
DR   SUPFAM; SSF50203; SSF50203; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Enterotoxin; Plasmid; Signal; Toxin; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..124
FT                   /note="Heat-labile enterotoxin B chain"
FT                   /id="PRO_0000405304"
FT   DISULFID        30..107
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   124 AA;  14028 MW;  5346BD38B32354C2 CRC64;
     MNKVKCYVLF TALLSSLCAY GAPQSITELC SEYRNTQIYT INDKILSYTE SMAGKREMVI
     ITFKSGATFQ VEVPGSQHID SQKKAIERMK DTLRITYLTE TKIDKLCVWN NKTPNSIAAI
     SMEN