ELBOW_DROME
ID ELBOW_DROME Reviewed; 553 AA.
AC Q9VJS8; Q7KT93; Q8IGL9; Q8MTC6; Q9NKC3;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 4.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein Elbow;
GN Name=elB; ORFNames=CG4220;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D), FUNCTION, SELF-ASSOCIATION,
RP INTERACTION WITH GRO AND NOC, AND DEVELOPMENTAL STAGE.
RX PubMed=12117809; DOI=10.1242/dev.129.15.3585;
RA Dorfman R., Glazer L., Weihe U., Wernet M.F., Shilo B.-Z.;
RT "Elbow and Noc define a family of zinc finger proteins controlling
RT morphogenesis of specific tracheal branches.";
RL Development 129:3585-3596(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=14757638; DOI=10.1242/dev.00979;
RA Weihe U., Dorfman R., Wernet M.F., Cohen S.M., Milan M.;
RT "Proximodistal subdivision of Drosophila legs and wings: the elbow-no
RT ocelli gene complex.";
RL Development 131:767-774(2004).
RN [6]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=17014842; DOI=10.1016/j.ydbio.2006.07.050;
RA Luque C.M., Milan M.;
RT "Growth control in the proliferative region of the Drosophila eye-head
RT primordium: the elbow-noc gene complex.";
RL Dev. Biol. 301:327-339(2007).
CC -!- FUNCTION: May negatively regulate Notch-induced cell proliferation in
CC the eye-head primordium. May act in leg and wing primordia to
CC negatively regulate body-wall specifying genes and thereby promote
CC appendage formation. Required for tracheal development.
CC {ECO:0000269|PubMed:12117809, ECO:0000269|PubMed:14757638,
CC ECO:0000269|PubMed:17014842}.
CC -!- SUBUNIT: Self-associates. Interacts with gro and noc.
CC {ECO:0000269|PubMed:12117809}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=D;
CC IsoId=Q9VJS8-3; Sequence=Displayed;
CC Name=C;
CC IsoId=Q9VJS8-2; Sequence=VSP_054449;
CC -!- DEVELOPMENTAL STAGE: Expressed in tracheal pit cells from stage 11. At
CC stage 12, expression becomes restricted to lateral anterior and
CC posterior tracheal branches. Expressed in the highly proliferative
CC region of the eye-head primordium. Expressed in the distal regions of
CC leg and wing imaginal disks. {ECO:0000269|PubMed:12117809,
CC ECO:0000269|PubMed:14757638, ECO:0000269|PubMed:17014842}.
CC -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
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DR EMBL; AY115567; AAM48283.1; -; mRNA.
DR EMBL; AE014134; AAS64707.1; -; Genomic_DNA.
DR EMBL; BT001713; AAN71468.1; -; mRNA.
DR RefSeq; NP_523566.4; NM_078842.5. [Q9VJS8-3]
DR RefSeq; NP_995712.1; NM_205990.2. [Q9VJS8-2]
DR AlphaFoldDB; Q9VJS8; -.
DR BioGRID; 60868; 32.
DR IntAct; Q9VJS8; 7.
DR STRING; 7227.FBpp0089383; -.
DR PaxDb; Q9VJS8; -.
DR DNASU; 34844; -.
DR EnsemblMetazoa; FBtr0080637; FBpp0089383; FBgn0004858. [Q9VJS8-2]
DR EnsemblMetazoa; FBtr0342915; FBpp0309706; FBgn0004858. [Q9VJS8-3]
DR GeneID; 34844; -.
DR KEGG; dme:Dmel_CG4220; -.
DR CTD; 34844; -.
DR FlyBase; FBgn0004858; elB.
DR VEuPathDB; VectorBase:FBgn0004858; -.
DR eggNOG; ENOG502QUYV; Eukaryota.
DR GeneTree; ENSGT00390000014618; -.
DR InParanoid; Q9VJS8; -.
DR OMA; PYYPHYT; -.
DR SignaLink; Q9VJS8; -.
DR BioGRID-ORCS; 34844; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 34844; -.
DR PRO; PR:Q9VJS8; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0004858; Expressed in spermathecum and 35 other tissues.
DR Genevisible; Q9VJS8; DM.
DR GO; GO:0000228; C:nuclear chromosome; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001752; P:compound eye photoreceptor fate commitment; IGI:FlyBase.
DR GO; GO:0035214; P:eye-antennal disc development; IMP:UniProtKB.
DR GO; GO:0048737; P:imaginal disc-derived appendage development; IMP:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:FlyBase.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0007424; P:open tracheal system development; IMP:FlyBase.
DR GO; GO:0035220; P:wing disc development; IMP:UniProtKB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Metal-binding;
KW Notch signaling pathway; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..553
FT /note="Zinc finger protein Elbow"
FT /id="PRO_0000292213"
FT ZN_FING 437..466
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 59..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..553
FT /note="Interaction with noc"
FT REGION 287..480
FT /note="Self-association"
FT REGION 388..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 24
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_054449"
FT CONFLICT 66
FT /note="H -> Q (in Ref. 1; AAM48283)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="G -> S (in Ref. 1; AAM48283)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 553 AA; 55876 MW; 413A7151068DE434 CRC64;
MLQSSNHHYL RPDYMTAAAA PTAQLDNKSS PLALLAQTCS AIGADTTNPK LLAANIEKST
KQLQHHPKGS SGSGGSGSFG LSQQASMDGS ARDKSSPVSS HSSSVSTGSV EQQQLPPAHG
SSSSSKPTPT TFKPYEPNNN ISNITTAADC GATNLSSNNT SAQQRVKTPK SMTNGGGQRC
DSNQSASSQH RESPTAAGSL RRTPTSGLAG GVMQHNGSPG LPPTASTTPG RSNSKESAAM
HSPSAAAAAA AAAAQIASSN RLQEAALAAA KEANYVKALH AASQQGSASA AAAAASYYPP
GYGSPYSMDL MTASSLMSPH HAMFKASAMN PYLNYARMKG LTEQSMMAAT PNVCRDPYCT
GCPASPHYIN KAAGQPCPAG CPQCEGGGGG GGGSSKSSGS QGGSGGSSSA AAAAAAAAAS
SYHAQLAALA AASQMPYVCS WIGSDAAYCG KRFGTSDDLF QHLRTHTASV PDAVLSAAAA
GGIPPNHPLF QRTYPTPPLS PLSAARYHPY GKPSMLPPSL APPGMPGLPP HPALAQYFAP
YSLYGPRMGS SHP
