ELCC_PHANO
ID ELCC_PHANO Reviewed; 562 AA.
AC Q0UI03;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=MFS-type efflux pump elcC {ECO:0000303|PubMed:28251756};
DE AltName: Full=Elsinochrome C biosynthesis cluster protein C {ECO:0000303|PubMed:28251756};
GN Name=elcC {ECO:0000303|PubMed:28251756}; ORFNames=SNOG_08611;
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
RN [2]
RP INDUCTION, AND FUNCTION.
RX PubMed=28251756; DOI=10.1111/1462-2920.13711;
RA Chooi Y.H., Zhang G., Hu J., Muria-Gonzalez M.J., Tran P.N., Pettitt A.,
RA Maier A.G., Barrow R.A., Solomon P.S.;
RT "Functional genomics-guided discovery of a light-activated phytotoxin in
RT the wheat pathogen Parastagonospora nodorum via pathway activation.";
RL Environ. Microbiol. 19:1975-1986(2017).
CC -!- FUNCTION: MFS-type efflux pump; part of the gene cluster that mediates
CC the biosynthesis of elsinochrome C, a perelyenequinone phytotoxin
CC structurally similar to cercosporin. {ECO:0000269|PubMed:28251756}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expression is up-regulated during the late stage of
CC P.nodorum wheat leaf infection and is controlled by the cluster
CC specific transporter elcR. {ECO:0000269|PubMed:28251756}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000305}.
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DR EMBL; CH445337; EAT83779.2; -; Genomic_DNA.
DR RefSeq; XP_001798920.1; XM_001798868.1.
DR AlphaFoldDB; Q0UI03; -.
DR SMR; Q0UI03; -.
DR STRING; 13684.SNOT_08611; -.
DR EnsemblFungi; SNOT_08611; SNOT_08611; SNOG_08611.
DR GeneID; 5975819; -.
DR KEGG; pno:SNOG_08611; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_000960_22_1_1; -.
DR InParanoid; Q0UI03; -.
DR OrthoDB; 627633at2759; -.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..562
FT /note="MFS-type efflux pump elcC"
FT /id="PRO_0000449868"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 515..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 448
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 562 AA; 60304 MW; 30784445AB50C1F9 CRC64;
MTGAKTNQVD QRPLSITDLL HFIPYDLQQT FLFEAILSYG KIYNLYPIKW VFLIALALFE
IGSLICGAAP SSVGLIMGRV VAGIGSGGLF AGAILLVAEF KPLNERAFYN GMLGAMYSVA
SVAGPLMGGA FTERVTWRLC FYINLPLGVV TAVIVFLLVP NNYDSGRDSR RGLPLKKKLQ
EMDLYGLVVL VPTIICILLA TQWGGTKYSW GNARIIALFV VGFVLFVAFV VIEIWQGDRA
IVPPSLVKRR TVWACSIFSF CLFGSFLVVA YFLPLWFQAI KGDTATESGI HNLPSILGTT
IFSVAAGGMV FGLGYYTWAC ILGSVLAAVG AGLLSTLEVD SNAAKWIGYQ VLYGAGCGFG
LNQPLIAIQA ALPDFQKSEG TAVVIFMQTF GGTIAIAVAQ NVFNNKLVSN ILAAGIPVDP
AALLSVGATK LQGLVQPQFF GRLQLAYNDS ITQTFYVAVA TAGLSMAGSI LIPWLSVKQA
VAPEDAETAN TVMPFQHPSS DVDLAMPAIL RQSGEIASED SQSSDIEKVP RNNEVSTYDS
QTSEVEKSSV GSTNRKVESI RN
