ID   ELF1_BOVIN              Reviewed;         614 AA.
AC   A0JN51;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=ETS-related transcription factor Elf-1;
DE   AltName: Full=E74-like factor 1;
GN   Name=ELF1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that activates the LYN and BLK
CC       promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to the underphosphorylated form of RB. May interact with
CC       other transcription factors in order to regulate specific genes.
CC       Interacts with RUNX1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; BC126517; AAI26518.1; -; mRNA.
DR   RefSeq; NP_001071321.1; NM_001077853.1.
DR   RefSeq; XP_005213624.1; XM_005213567.3.
DR   AlphaFoldDB; A0JN51; -.
DR   SMR; A0JN51; -.
DR   STRING; 9913.ENSBTAP00000009677; -.
DR   PaxDb; A0JN51; -.
DR   PRIDE; A0JN51; -.
DR   Ensembl; ENSBTAT00000009677; ENSBTAP00000009677; ENSBTAG00000007356.
DR   GeneID; 505251; -.
DR   KEGG; bta:505251; -.
DR   CTD; 1997; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007356; -.
DR   VGNC; VGNC:28426; ELF1.
DR   eggNOG; KOG3804; Eukaryota.
DR   GeneTree; ENSGT00940000157039; -.
DR   HOGENOM; CLU_027279_1_0_1; -.
DR   InParanoid; A0JN51; -.
DR   OMA; HNYSGLT; -.
DR   OrthoDB; 837296at2759; -.
DR   TreeFam; TF318679; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000007356; Expressed in thymus and 106 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0001817; P:regulation of cytokine production; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR022084; TF_Elf_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF12310; Elf-1_N; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..614
FT                   /note="ETS-related transcription factor Elf-1"
FT                   /id="PRO_0000287130"
FT   DNA_BIND        208..290
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          159..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..339
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         110
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32519"
FT   MOD_RES         163
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32519"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32519"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32519"
FT   MOD_RES         187
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32519"
FT   MOD_RES         190
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P32519"
FT   MOD_RES         430
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32519"
SQ   SEQUENCE   614 AA;  66572 MW;  DB1CC8B3CA9F6D84 CRC64;
     MAAVVQQNDL VFEFASNVME DEQQLGDPAI FPAVIVEHVP GADILNSYAG LACVEEPNDM
     ITESSLDVAE EEIIDEDEDD ITLTVEASCH NGDETIETIE AAEALLNMDS PGPMLDEKRM
     NNSIFSSSED DMVVAPVTHV SVTLDGIPEV METQHVQETY AHSPGPSSPE QPKRKKGRKT
     KPPRPDSPTT TPNISVKKKN KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL
     VDSKAVSRLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKDLIYID
     DEDPSCSIES SDPSLSSTAT SSRNPASRSR ASSSPGIKGG ATTVLKPGNS KAAKPKDPME
     PVQPSEALRT VQSTQAPYPT QLFRTIHVVQ PVQAVPEAEA ASSMPEETLN PSVPSIRTIQ
     TPAQVPVVVS PGNQHLHTVT LQTVPITTVI ASADPSSAAG SQKFILQAIP SSQPMTVLKE
     NVVLQSQKPG SPPSIVLSPA HVQQVLTSSV PTVCNGTVSA ASAPSFSATT PMVTFSHHSS
     QLVAHPPGTV ITSVIKAQEA KTHIQEEVKK EVEDNEKQGT EDAEQQLQPY VMVVSNGFPS
     QAAIKNELLE PSSF