ELF1_MOUSE
ID ELF1_MOUSE Reviewed; 612 AA.
AC Q60775;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=ETS-related transcription factor Elf-1;
DE AltName: Full=E74-like factor 1;
GN Name=Elf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fibroblast;
RX PubMed=8666284; DOI=10.1016/0378-1119(96)00013-3;
RA Davis J.N., Roussel M.F.;
RT "Cloning and expression of the murine Elf-1 cDNA.";
RL Gene 171:265-269(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Transcription factor that activates the LYN and BLK
CC promoters. {ECO:0000250}.
CC -!- SUBUNIT: Binds to the underphosphorylated form of RB. May interact with
CC other transcription factors in order to regulate specific genes.
CC Interacts with RUNX1. Interacts with SP1; the interaction is inhibited
CC by glycosylation of SP1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Predominantly found in hematopoietic cells.
CC Detected in other cell types such as fibroblasts.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; U19617; AAB17097.1; -; mRNA.
DR EMBL; BC057134; AAH57134.1; -; mRNA.
DR CCDS; CCDS27301.1; -.
DR RefSeq; NP_001273340.1; NM_001286411.1.
DR RefSeq; NP_031946.1; NM_007920.4.
DR RefSeq; XP_011243248.1; XM_011244946.2.
DR RefSeq; XP_011243249.1; XM_011244947.1.
DR AlphaFoldDB; Q60775; -.
DR SMR; Q60775; -.
DR BioGRID; 199426; 6.
DR IntAct; Q60775; 1.
DR STRING; 10090.ENSMUSP00000046515; -.
DR iPTMnet; Q60775; -.
DR PhosphoSitePlus; Q60775; -.
DR EPD; Q60775; -.
DR jPOST; Q60775; -.
DR MaxQB; Q60775; -.
DR PaxDb; Q60775; -.
DR PRIDE; Q60775; -.
DR ProteomicsDB; 275451; -.
DR Antibodypedia; 906; 395 antibodies from 39 providers.
DR DNASU; 13709; -.
DR Ensembl; ENSMUST00000040131; ENSMUSP00000046515; ENSMUSG00000036461.
DR Ensembl; ENSMUST00000110835; ENSMUSP00000106459; ENSMUSG00000036461.
DR GeneID; 13709; -.
DR KEGG; mmu:13709; -.
DR UCSC; uc007utb.2; mouse.
DR CTD; 1997; -.
DR MGI; MGI:107180; Elf1.
DR VEuPathDB; HostDB:ENSMUSG00000036461; -.
DR eggNOG; KOG3804; Eukaryota.
DR GeneTree; ENSGT00940000157039; -.
DR HOGENOM; CLU_027279_1_0_1; -.
DR InParanoid; Q60775; -.
DR OMA; HNYSGLT; -.
DR OrthoDB; 837296at2759; -.
DR PhylomeDB; Q60775; -.
DR TreeFam; TF318679; -.
DR Reactome; R-MMU-8939247; RUNX1 regulates transcription of genes involved in interleukin signaling.
DR BioGRID-ORCS; 13709; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Elf1; mouse.
DR PRO; PR:Q60775; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q60775; protein.
DR Bgee; ENSMUSG00000036461; Expressed in peripheral lymph node and 227 other tissues.
DR ExpressionAtlas; Q60775; baseline and differential.
DR Genevisible; Q60775; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0001817; P:regulation of cytokine production; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR022084; TF_Elf_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF12310; Elf-1_N; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..612
FT /note="ETS-related transcription factor Elf-1"
FT /id="PRO_0000204086"
FT DNA_BIND 208..290
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 156..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P32519"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P32519"
FT MOD_RES 167
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P32519"
FT MOD_RES 168
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P32519"
FT MOD_RES 187
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P32519"
FT MOD_RES 190
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P32519"
FT MOD_RES 431
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P32519"
SQ SEQUENCE 612 AA; 66221 MW; 442F4C85142B31F0 CRC64;
MAAVVQQNDL VFEFASNGME DEQQLGDPAI FPAVIVEHVP GADILNSYAG LACVEEPNDM
ITESSLDVAE EEIIDDDDDD ITLTVEASCH NGDETIETIE AAEALLNIDS PSPPVLDEKQ
INNNIFSSSE DDIVAPITHV SVTLDGIPEV METQQVQETN ADSPGASSPE QRKRKKGRKT
KPPRPDSPTT TPNISVKKKN KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL
VDSKAVSRLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYID
DEDPSSSIES SDQSLSSTTA SSRNQANRSR VSSSPGIKGG AATILKPGNS KAANPKDPVE
VGQPSEVLRT VQPSQAPYPT QLFRTVHVVQ PVQAVPEEAT IASTMQEEAA NSSVPSIRTI
QASTQVPVVV SPGNQQLHTV TVPLTTVIAS IDPSSGAGSQ KFILQTIPSS QPMTVLKENV
MLQSQKPGSP SIVLSPTQVQ QVLTSNVQSI CNGAGSVASA PSFSATTPVV TFSRSSQLVA
HPPGTVITSV IKAQETKTLK QEVEKKAEDD LNEDAEKSAQ QPQPYVMVLS SSNGFSSQVA
VKQNELLEPN SF
