ID   ELF5_BOVIN              Reviewed;         255 AA.
AC   Q58DT0;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=ETS-related transcription factor Elf-5;
DE   AltName: Full=E74-like factor 5;
GN   Name=ELF5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Transcriptionally activator that may play a role in
CC       regulating the later stages of keratinocytes terminal differentiation.
CC       Binds to DNA sequences containing the consensus nucleotide core
CC       sequence GGA[AT] (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- DOMAIN: The PNT domain acts as a transcriptional activator.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; BT021517; AAX46364.1; -; mRNA.
DR   RefSeq; NP_001019740.1; NM_001024569.1.
DR   RefSeq; XP_005216443.1; XM_005216386.2.
DR   RefSeq; XP_015330338.1; XM_015474852.1.
DR   RefSeq; XP_015330339.1; XM_015474853.1.
DR   AlphaFoldDB; Q58DT0; -.
DR   SMR; Q58DT0; -.
DR   STRING; 9913.ENSBTAP00000016534; -.
DR   PaxDb; Q58DT0; -.
DR   PRIDE; Q58DT0; -.
DR   Ensembl; ENSBTAT00000016534; ENSBTAP00000016534; ENSBTAG00000012460.
DR   Ensembl; ENSBTAT00000074365; ENSBTAP00000063292; ENSBTAG00000012460.
DR   Ensembl; ENSBTAT00000074492; ENSBTAP00000073408; ENSBTAG00000012460.
DR   Ensembl; ENSBTAT00000085107; ENSBTAP00000067305; ENSBTAG00000012460.
DR   GeneID; 539420; -.
DR   KEGG; bta:539420; -.
DR   CTD; 2001; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012460; -.
DR   VGNC; VGNC:28430; ELF5.
DR   eggNOG; KOG3804; Eukaryota.
DR   GeneTree; ENSGT00940000160980; -.
DR   HOGENOM; CLU_048172_1_0_1; -.
DR   InParanoid; Q58DT0; -.
DR   OMA; NCLKASG; -.
DR   OrthoDB; 837296at2759; -.
DR   TreeFam; TF318679; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000012460; Expressed in mammary gland and 70 other tissues.
DR   ExpressionAtlas; Q58DT0; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR033069; Elf5.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   PANTHER; PTHR11849:SF15; PTHR11849:SF15; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..255
FT                   /note="ETS-related transcription factor Elf-5"
FT                   /id="PRO_0000204091"
FT   DOMAIN          33..119
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        163..244
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
SQ   SEQUENCE   255 AA;  30090 MW;  50FBD86AAB6FEC91 CRC64;
     MLDSVTHSTF LPNTSFCDPL MSWTDLFSNE EYYPAFEHQT ACDSYWTSVH PEYWTKRHVW
     EWLQFCCDQY KLDANCISFC HFNISGLQLC GMTQEEFMEA AGVCGEYLYF ILQSIRSQGY
     SFFNDPDETK ATLKDYADSS CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR DLLLSPEENC
     GILEWEDREQ GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG ILERVDRRLV
     YKFGKNAHGW QEDKL