ELF5_MOUSE
ID ELF5_MOUSE Reviewed; 253 AA.
AC Q8VDK3; Q921H5; Q9Z2K6;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=ETS-related transcription factor Elf-5;
DE AltName: Full=E74-like factor 5;
GN Name=Elf5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Lung;
RX PubMed=9840936; DOI=10.1038/sj.onc.1202198;
RA Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S.,
RA Kola I.;
RT "A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS
RT genes and maps to human chromosome 11p13-15, a region subject to LOH and
RT rearrangement in human carcinoma cell lines.";
RL Oncogene 17:2719-2732(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND DOMAIN.
RX PubMed=16704374; DOI=10.1042/bj20060375;
RA Choi Y.S., Sinha S.;
RT "Determination of the consensus DNA-binding sequence and a transcriptional
RT activation domain for ESE-2.";
RL Biochem. J. 398:497-507(2006).
CC -!- FUNCTION: Transcriptionally activator that may play a role in
CC regulating the later stages of keratinocytes terminal differentiation
CC (By similarity). Binds to DNA sequences containing the consensus
CC nucleotide core sequence GGA[AT]. Transcriptionally activates the TK
CC promoter. {ECO:0000250, ECO:0000269|PubMed:16704374,
CC ECO:0000269|PubMed:9840936}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC -!- TISSUE SPECIFICITY: Expressed in lung, kidney, stomach, brain, ovaries,
CC tongue, bladder and mammary glands. {ECO:0000269|PubMed:9840936}.
CC -!- DEVELOPMENTAL STAGE: In the neonatal stage, and during embryogenesis on
CC days 16, 17 and 19, an expression pattern similar to the adult was
CC observed. In addition at stage 16, expression was detected in small
CC intestine.
CC -!- DOMAIN: The PNT domain acts as a transcriptional activator.
CC {ECO:0000269|PubMed:16704374}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; AF049702; AAC79754.1; -; mRNA.
DR EMBL; BC021629; AAH21629.1; -; mRNA.
DR EMBL; BC012424; AAH12424.1; -; mRNA.
DR CCDS; CCDS16477.1; -.
DR RefSeq; NP_001139285.1; NM_001145813.1.
DR RefSeq; NP_034255.2; NM_010125.3.
DR RefSeq; XP_006498768.1; XM_006498705.1.
DR AlphaFoldDB; Q8VDK3; -.
DR SMR; Q8VDK3; -.
DR BioGRID; 199428; 104.
DR IntAct; Q8VDK3; 1.
DR STRING; 10090.ENSMUSP00000028609; -.
DR iPTMnet; Q8VDK3; -.
DR PhosphoSitePlus; Q8VDK3; -.
DR PaxDb; Q8VDK3; -.
DR PRIDE; Q8VDK3; -.
DR Antibodypedia; 25870; 268 antibodies from 29 providers.
DR DNASU; 13711; -.
DR Ensembl; ENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186.
DR Ensembl; ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186.
DR Ensembl; ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186.
DR GeneID; 13711; -.
DR KEGG; mmu:13711; -.
DR UCSC; uc008liv.2; mouse.
DR CTD; 2001; -.
DR MGI; MGI:1335079; Elf5.
DR VEuPathDB; HostDB:ENSMUSG00000027186; -.
DR eggNOG; KOG3804; Eukaryota.
DR GeneTree; ENSGT00940000160980; -.
DR HOGENOM; CLU_048172_1_0_1; -.
DR InParanoid; Q8VDK3; -.
DR OMA; NTMVCES; -.
DR OrthoDB; 837296at2759; -.
DR PhylomeDB; Q8VDK3; -.
DR TreeFam; TF318679; -.
DR BioGRID-ORCS; 13711; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Elf5; mouse.
DR PRO; PR:Q8VDK3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VDK3; protein.
DR Bgee; ENSMUSG00000027186; Expressed in seminal vesicle and 93 other tissues.
DR ExpressionAtlas; Q8VDK3; baseline and differential.
DR Genevisible; Q8VDK3; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007398; P:ectoderm development; IMP:MGI.
DR GO; GO:0001712; P:ectodermal cell fate commitment; IGI:MGI.
DR GO; GO:0060644; P:mammary gland epithelial cell differentiation; IGI:MGI.
DR GO; GO:0060806; P:negative regulation of cell differentiation involved in embryonic placenta development; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035019; P:somatic stem cell population maintenance; IMP:MGI.
DR GO; GO:0060707; P:trophoblast giant cell differentiation; IMP:MGI.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR033069; Elf5.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR PANTHER; PTHR11849:SF15; PTHR11849:SF15; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..253
FT /note="ETS-related transcription factor Elf-5"
FT /id="PRO_0000204093"
FT DOMAIN 33..119
FT /note="PNT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT DNA_BIND 161..242
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT CONFLICT 31
FT /note="D -> E (in Ref. 2; AAH21629)"
FT /evidence="ECO:0000305"
FT CONFLICT 228
FT /note="G -> R (in Ref. 1; AAC79754)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 253 AA; 29873 MW; 3FC4799F77AFCF48 CRC64;
MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH PEYWTKRHVW
EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA AGICGEYLYF ILQNIRSQGY
SFFNDAEETK TGIKDYADSS CLKTSGIKSQ DCHSRTSLQS SHLWEFVRDL LLSPEENCGI
LEWEDREQGI FRVVKSEALA KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK
FGKNAHGWQE EKL
