ID   ELFA_ECOLI              Reviewed;         179 AA.
AC   P75855;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Fimbrial subunit ElfA;
DE   Flags: Precursor;
GN   Name=elfA; Synonyms=ycbQ; OrderedLocusNames=b0938, JW5122;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA   Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA   Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA   Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA   Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA   Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA   Horiuchi T.;
RT   "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 12.7-28.0 min region on the linkage map.";
RL   DNA Res. 3:137-155(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION AS A PILIN, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=20345943; DOI=10.1111/j.1462-2920.2010.02202.x;
RA   Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.;
RT   "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-
RT   usher fimbriae with distinct surface specificities.";
RL   Environ. Microbiol. 12:1957-1977(2010).
CC   -!- FUNCTION: Part of the elfADCG-ycbUVF fimbrial operon, which promotes
CC       adhesion of bacteria to different abiotic surfaces. ElfA is the major
CC       fimbrial subunit produced by this operon.
CC       {ECO:0000269|PubMed:20345943}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000269|PubMed:20345943}.
CC   -!- INDUCTION: Expression is negatively regulated by H-NS and subjected to
CC       cAMP receptor protein (CRP)-mediated catabolite repression.
CC       {ECO:0000269|PubMed:20345943}.
CC   -!- MISCELLANEOUS: The operon is cryptic under classical laboratory
CC       conditions, but is functional when constitutively expressed.
CC       {ECO:0000305|PubMed:20345943}.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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DR   EMBL; U00096; AAC74024.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAA35693.2; -; Genomic_DNA.
DR   PIR; A64834; A64834.
DR   RefSeq; NP_415458.2; NC_000913.3.
DR   RefSeq; WP_000750293.1; NZ_SSZK01000002.1.
DR   AlphaFoldDB; P75855; -.
DR   SMR; P75855; -.
DR   BioGRID; 4262988; 188.
DR   BioGRID; 852604; 1.
DR   IntAct; P75855; 1.
DR   STRING; 511145.b0938; -.
DR   PaxDb; P75855; -.
DR   EnsemblBacteria; AAC74024; AAC74024; b0938.
DR   EnsemblBacteria; BAA35693; BAA35693; BAA35693.
DR   GeneID; 948306; -.
DR   KEGG; ecj:JW5122; -.
DR   KEGG; eco:b0938; -.
DR   PATRIC; fig|1411691.4.peg.1336; -.
DR   EchoBASE; EB3473; -.
DR   eggNOG; COG3539; Bacteria.
DR   HOGENOM; CLU_088965_0_0_6; -.
DR   InParanoid; P75855; -.
DR   OMA; APACTIA; -.
DR   PhylomeDB; P75855; -.
DR   BioCyc; EcoCyc:G6480-MON; -.
DR   PRO; PR:P75855; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009289; C:pilus; IDA:EcoCyc.
DR   GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IMP:EcoCyc.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   Pfam; PF00419; Fimbrial; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   1: Evidence at protein level;
KW   Fimbrium; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..179
FT                   /note="Fimbrial subunit ElfA"
FT                   /id="PRO_0000009254"
SQ   SEQUENCE   179 AA;  18680 MW;  52261CBC9122C986 CRC64;
     MKKSVLTAFI TVVCATSSVM AADDNAITDG SVTFNGKVIA PACTLVAATK DSVVTLPDVS
     ATKLQTNGQV SGVQIDVPIE LKDCDTTVTK NATFTFNGTA DTTQITAFAN QASSDAATNV
     ALQMYMNDGT TAITPDTETG NILLQDGDQT LTFKVDYIAT GKATSGNVNA VTNFHINYY