ELFC_ECO57
ID ELFC_ECO57 Reviewed; 866 AA.
AC Q8XDD1; Q7AG41; Q7AG42; Q8XDD2;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Probable outer membrane usher protein ElfC;
DE Flags: Precursor;
GN Name=elfC; Synonyms=ycbS; OrderedLocusNames=ECs1023/ECs1024, Z1288/Z1289;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
RN [3]
RP FUNCTION, INDUCTION, AND GENE NAME.
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=19508558; DOI=10.1111/j.1462-2920.2009.01906.x;
RA Samadder P., Xicohtencatl-Cortes J., Saldana Z., Jordan D., Tarr P.I.,
RA Kaper J.B., Giron J.A.;
RT "The Escherichia coli ycbQRST operon encodes fimbriae with laminin-binding
RT and epithelial cell adherence properties in Shiga-toxigenic E.coli
RT O157:H7.";
RL Environ. Microbiol. 11:1815-1826(2009).
CC -!- FUNCTION: Part of the elfADCG fimbrial operon, which could be required
CC for adherence to host epithelial cells. Could be involved in the export
CC and assembly of the ElfA fimbrial subunits across the outer membrane.
CC {ECO:0000269|PubMed:19508558}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- INDUCTION: Induced in the presence of epithelial cells.
CC {ECO:0000269|PubMed:19508558}.
CC -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG55425.1; Type=Frameshift; Note=This may be a natural frameshift.; Evidence={ECO:0000305};
CC Sequence=AAG55426.1; Type=Frameshift; Note=This may be a natural frameshift.; Evidence={ECO:0000305};
CC Sequence=BAB34446.1; Type=Frameshift; Note=This may be a natural frameshift.; Evidence={ECO:0000305};
CC Sequence=BAB34447.1; Type=Frameshift; Note=This may be a natural frameshift.; Evidence={ECO:0000305};
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DR EMBL; AE005174; AAG55425.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AE005174; AAG55426.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BA000007; BAB34446.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BA000007; BAB34447.1; ALT_FRAME; Genomic_DNA.
DR PIR; E85620; E85620.
DR PIR; F85620; F85620.
DR PIR; G90756; G90756.
DR PIR; H90756; H90756.
DR AlphaFoldDB; Q8XDD1; -.
DR SMR; Q8XDD1; -.
DR STRING; 155864.EDL933_1205; -.
DR EnsemblBacteria; AAG55425; AAG55425; Z1288.
DR EnsemblBacteria; AAG55426; AAG55426; Z1289.
DR KEGG; ece:Z1288; -.
DR KEGG; ece:Z1289; -.
DR eggNOG; COG3188; Bacteria.
DR HOGENOM; CLU_1364466_0_0_6; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015473; F:fimbrial usher porin activity; IEA:InterPro.
DR GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR Gene3D; 2.60.40.2070; -; 1.
DR Gene3D; 2.60.40.2610; -; 1.
DR Gene3D; 3.10.20.410; -; 1.
DR InterPro; IPR000015; Fimb_usher.
DR InterPro; IPR018030; Fimbrial_membr_usher_CS.
DR InterPro; IPR042186; FimD_plug_dom.
DR InterPro; IPR025949; PapC-like_C.
DR InterPro; IPR043142; PapC-like_C_sf.
DR InterPro; IPR025885; PapC_N.
DR InterPro; IPR037224; PapC_N_sf.
DR PANTHER; PTHR30451; PTHR30451; 1.
DR Pfam; PF13953; PapC_C; 1.
DR Pfam; PF13954; PapC_N; 1.
DR Pfam; PF00577; Usher; 1.
DR SUPFAM; SSF141729; SSF141729; 1.
DR PROSITE; PS01151; FIMBRIAL_USHER; 1.
PE 2: Evidence at transcript level;
KW Cell outer membrane; Fimbrium biogenesis; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane beta strand; Transport.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..866
FT /note="Probable outer membrane usher protein ElfC"
FT /id="PRO_0000413219"
SQ SEQUENCE 866 AA; 95219 MW; CD3867AEF6D4F970 CRC64;
MYRTHRQHSL LSSGGVPSFI GGLVVFVSAA FNAQAETWFD PAFFKDDPSM VADLSRFEKG
QKITPGVYRV DIVLNQTIVD TRNVNFVEIT PEKGIAACLT TESLDAMGVN TDAFPAFKQL
DKQACAPLAE IIPDASVTFN VNKLRLEISV PQIAIKSNAR GYVPPERWDE GINALLLGYS
FSGANSIHSS ADSDSGDSYF LNLNSGVNLG PWRLRNNSTW SRSSGQTAEW KNLSSYLQRA
VIPLKGELTV GDDYTAGDFF DSVSFRGVQL ASDDNMLPDS LKGFAPVVRG IAKSNAQITI
KQNGYTIYQT YVSPGAFEIS DIYSTSSSGD LLVEIKEADG SVNSYSVPFS SVPLLQRQGR
IKYAVTLAKY RTNSNEQQES KFAQATLQWG GPWGTTWYGG GQYAEYYRAA MFGLGFNLGD
FGAISFDVTQ AKSTLADQSE HKGQSYRFLY AKTLNQLGTN FQLMGYRYST SGFYTLSDTM
YKHMDGYEFN DGDDEDTPMW SRYYNLFYTK RGKLQVNISQ QLSEYGSFYL SGSQQTYWHT
DQQDRLLQFG YNTQIKDLSL GISWNYSKSR GQPDADQVFA LNFSLPLNLL LSRSNDSYTS
KKNYAWMTSN TSIDNEGHTT QNLGLTETLL DDGNLSYSVQ QGYNSEGKTA NGSASMDYKG
VFADARVGYN YSDNGSQQQL NYALSGSLVA HSQGITLGQS LGETNVLIAA PGAENTRVAN
STGLKTDWRG YTVVPYATSY RENRIALDAA SLKRNVDLEN AVVNVVPTKG ALVLAEFNAH
AGARVLMKTS KQGISLRFGA IATLDGVQTN SGIIDDDGSL YMAGLPAKGT ITVRWGEAPD
QICHISYELT EQQINSAITR MDAICR
