ID   ELFC_ECOLI              Reviewed;         866 AA.
AC   P75857;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Probable outer membrane usher protein ElfC;
DE   Flags: Precursor;
GN   Name=elfC; Synonyms=ycbS; OrderedLocusNames=b0940, JW0923;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA   Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA   Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA   Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA   Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA   Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA   Horiuchi T.;
RT   "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 12.7-28.0 min region on the linkage map.";
RL   DNA Res. 3:137-155(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=20345943; DOI=10.1111/j.1462-2920.2010.02202.x;
RA   Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.;
RT   "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-
RT   usher fimbriae with distinct surface specificities.";
RL   Environ. Microbiol. 12:1957-1977(2010).
CC   -!- FUNCTION: Part of the elfADCG-ycbUVF fimbrial operon, which promotes
CC       adhesion of bacteria to different abiotic surfaces. Could be involved
CC       in the export and assembly of the ElfA fimbrial subunits across the
CC       outer membrane. {ECO:0000269|PubMed:20345943}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- INDUCTION: Expression is negatively regulated by H-NS and subjected to
CC       cAMP receptor protein (CRP)-mediated catabolite repression.
CC       {ECO:0000269|PubMed:20345943}.
CC   -!- MISCELLANEOUS: The operon is cryptic under classical laboratory
CC       conditions, but is functional when constitutively expressed.
CC       {ECO:0000305|PubMed:20345943}.
CC   -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
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DR   EMBL; U00096; AAC74026.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA35695.1; -; Genomic_DNA.
DR   PIR; C64834; C64834.
DR   RefSeq; NP_415460.1; NC_000913.3.
DR   RefSeq; WP_000286312.1; NZ_SSZK01000002.1.
DR   AlphaFoldDB; P75857; -.
DR   SMR; P75857; -.
DR   BioGRID; 4263120; 168.
DR   STRING; 511145.b0940; -.
DR   PaxDb; P75857; -.
DR   PRIDE; P75857; -.
DR   EnsemblBacteria; AAC74026; AAC74026; b0940.
DR   EnsemblBacteria; BAA35695; BAA35695; BAA35695.
DR   GeneID; 946934; -.
DR   KEGG; ecj:JW0923; -.
DR   KEGG; eco:b0940; -.
DR   PATRIC; fig|1411691.4.peg.1334; -.
DR   EchoBASE; EB3475; -.
DR   eggNOG; COG3188; Bacteria.
DR   HOGENOM; CLU_009120_3_1_6; -.
DR   InParanoid; P75857; -.
DR   OMA; FQLTGYR; -.
DR   PhylomeDB; P75857; -.
DR   BioCyc; EcoCyc:G6482-MON; -.
DR   PRO; PR:P75857; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015473; F:fimbrial usher porin activity; IBA:GO_Central.
DR   GO; GO:0008201; F:heparin binding; IDA:EcoCyc.
DR   GO; GO:0009297; P:pilus assembly; IBA:GO_Central.
DR   Gene3D; 2.60.40.2070; -; 1.
DR   Gene3D; 2.60.40.2610; -; 1.
DR   Gene3D; 3.10.20.410; -; 1.
DR   InterPro; IPR000015; Fimb_usher.
DR   InterPro; IPR018030; Fimbrial_membr_usher_CS.
DR   InterPro; IPR042186; FimD_plug_dom.
DR   InterPro; IPR025949; PapC-like_C.
DR   InterPro; IPR043142; PapC-like_C_sf.
DR   InterPro; IPR025885; PapC_N.
DR   InterPro; IPR037224; PapC_N_sf.
DR   PANTHER; PTHR30451; PTHR30451; 1.
DR   Pfam; PF13953; PapC_C; 1.
DR   Pfam; PF13954; PapC_N; 1.
DR   Pfam; PF00577; Usher; 1.
DR   SUPFAM; SSF141729; SSF141729; 1.
DR   PROSITE; PS01151; FIMBRIAL_USHER; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Fimbrium biogenesis; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..866
FT                   /note="Probable outer membrane usher protein ElfC"
FT                   /id="PRO_0000009330"
SQ   SEQUENCE   866 AA;  95242 MW;  0004DC5E9F1F5796 CRC64;
     MYRTHRQHSL LSSGGVPSFI GGLVVFVSAA FNAQAETWFD PAFFKDDPSM VADLSRFEKG
     QKITPGVYRV DIVLNQTIVD TRNVNFVEIT PEKGIAACLT TESLDAMGVN TDAFPAFKQL
     DKQACVPLAE IIPDASVTFN VNKLRLEISV PQIAIKSNAR GYVPPERWDE GINALLLGYS
     FSGANSIHSS ADSDSGDSYF LNLNSGVNLG PWRLRNNSTW SRSSGQTAEW KNLSSYLQRA
     VIPLKGELTV GDDYTAGDFF DSVSFRGVQL ASDDNMLPDS LKGFAPVVRG IAKSNAQITI
     KQNGYTIYQT YVSPGAFEIS DLYSTSSSGD LLVEIKEADG SVNSYSVPFS SVPLLQRQGR
     IKYAVTLAKY RTNSNEQQES KFAQATLQWG GPWGTTWYGG GQYAEYYRAA MFGLGFNLGD
     FGAISFDATQ AKSTLADQSE HKGQSYRFLY AKTLNHLGTN FQLMGYRYST SGFYTLSDTM
     YKHMDGYEFN DGDDEDTPMW SRYYNLFYTK RGKLQVNISQ QLGEYGSFYL SGSQQTYWHT
     DQQDRLLQFG YNTQIKDLSL GISWNYSKSR GQPDADQVFA LNFSLPLNLL LPRSNDSYTR
     KKNYAWMTSN TSIDNEGHTT QNLGLTETLL DDGNLSYSVQ QGYNSEGKTA NGSASMDYKG
     AFADARVGYN YSDNGSQQQL NYALSGSLVA HSQGITLGQS LGETNVLIAA PGAENTRVAN
     STGLKTDWRG YTVVPYATSY RENRIALDAA SLKRNVDLEN AVVNVVPTKG ALVLAEFNAH
     AGARVLMKTS KQGIPLRFGA IATLDGVQAN SGIIDDDGSL YMAGLPAKGT ISVRWGEAPD
     QICHINYELT EQQINSAITR MDAICR