ID   ELH1_APLPA              Reviewed;         263 AA.
AC   P17685;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=ELH type 1;
DE   Contains:
DE     RecName: Full=Alpha-bag cell peptide;
DE              Short=Alpha-BCP;
DE   Contains:
DE     RecName: Full=Beta-bag cell peptide;
DE              Short=Beta-BCP;
DE   Contains:
DE     RecName: Full=Gamma-bag cell peptide;
DE              Short=Gamma-BCP;
DE   Contains:
DE     RecName: Full=Egg-laying hormone;
DE              Short=ELH;
DE   Contains:
DE     RecName: Full=Acidic peptide;
DE   Flags: Precursor;
GN   Name=ELH1;
OS   Aplysia parvula (Dwarf sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3734873; DOI=10.1523/jneurosci.06-07-02026.1986;
RA   Nambu J.R., Scheller R.H.;
RT   "Egg-laying hormone genes of Aplysia: evolution of the ELH gene family.";
RL   J. Neurosci. 6:2026-2036(1986).
CC   -!- FUNCTION: ELH acts as a neurotransmitter locally, upon neurons of the
CC       abdominal ganglion and as a hormone by diffusing into the circulating
CC       hemolymph and modulating the activity of other organs. It specifically
CC       causes contraction of smooth muscle in the ovotestis and expulsion of
CC       the egg string.
CC   -!- FUNCTION: Alpha-BCP decreases the activity of a cluster of neurons in
CC       the left upper quadrant of the abdominal ganglion.
CC   -!- FUNCTION: Beta-BCP specifically excites 2 neurons, L1 and R1, in the
CC       abdominal ganglion.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Bag cell neurons.
CC   -!- SIMILARITY: Belongs to the molluscan ELH family. {ECO:0000305}.
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DR   EMBL; M30048; AAA27765.1; -; Genomic_DNA.
DR   PIR; A26147; A26147.
DR   AlphaFoldDB; P17685; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR003424; ELH.
DR   Pfam; PF02323; ELH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000250"
FT   PROPEP          30..85
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000001821"
FT   PEPTIDE         88..92
FT                   /note="Beta-bag cell peptide"
FT                   /id="PRO_0000001822"
FT   PEPTIDE         95..99
FT                   /note="Gamma-bag cell peptide"
FT                   /id="PRO_0000001823"
FT   PROPEP          102..140
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000001824"
FT   PEPTIDE         142..150
FT                   /note="Alpha-bag cell peptide"
FT                   /id="PRO_0000001825"
FT   PROPEP          154..195
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000001826"
FT   PEPTIDE         198..233
FT                   /note="Egg-laying hormone"
FT                   /id="PRO_0000001827"
FT   PEPTIDE         237..263
FT                   /note="Acidic peptide"
FT                   /id="PRO_0000001828"
FT   REGION          154..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         233
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   263 AA;  29676 MW;  E0C69F9E3E5FFF29 CRC64;
     MGRPSYRSAA AISLLMCLIL SALCASSESA VVHGSSFATE RAVKSSPYLV LSPADEMVGM
     STANEAFDKS PSYYDDDDDD FVKNEKRRLR FHKRRIRFNK RPQEVSGLKP VMMSRASASA
     DENSLFDLYN TDGAMYQRDL RAPRLRFYSL RKRAAGDEDK SEENNPETES HSRRKRSALT
     PSIRSLRSSL ESGIAKRISI NQDLKAIADM LIVEQKQERE KYLADLRQRL LNKGKRSSEV
     ALAASDKGDE ERELLNTLSN LLE