ID   ELH2_APLPA              Reviewed;         252 AA.
AC   P17686;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=ELH type 2;
DE   Contains:
DE     RecName: Full=Alpha-bag cell peptide;
DE              Short=Alpha-BCP;
DE   Contains:
DE     RecName: Full=Beta-bag cell peptide;
DE              Short=Beta-BCP;
DE   Contains:
DE     RecName: Full=Gamma-bag cell peptide;
DE              Short=Gamma-BCP;
DE   Contains:
DE     RecName: Full=Egg-laying hormone;
DE              Short=ELH;
DE   Contains:
DE     RecName: Full=Acidic peptide;
DE   Flags: Precursor; Fragment;
GN   Name=ELH2;
OS   Aplysia parvula (Dwarf sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND AMIDATION AT LYS-222.
RX   PubMed=3734873; DOI=10.1523/jneurosci.06-07-02026.1986;
RA   Nambu J.R., Scheller R.H.;
RT   "Egg-laying hormone genes of Aplysia: evolution of the ELH gene family.";
RL   J. Neurosci. 6:2026-2036(1986).
CC   -!- FUNCTION: ELH acts as a neurotransmitter locally, upon neurons of the
CC       abdominal ganglion and as a hormone by diffusing into the circulating
CC       hemolymph and modulating the activity of other organs. It specifically
CC       causes contraction of smooth muscle in the ovotestis and expulsion of
CC       the egg string.
CC   -!- FUNCTION: Alpha-BCP decreases the activity of a cluster of neurons in
CC       the left upper quadrant of the abdominal ganglion.
CC   -!- FUNCTION: Beta-BCP specifically excites 2 neurons, L1 and R1, in the
CC       abdominal ganglion.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Bag cell neurons.
CC   -!- SIMILARITY: Belongs to the molluscan ELH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M30049; AAA27766.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; P17686; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR003424; ELH.
DR   Pfam; PF02323; ELH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Secreted; Signal.
FT   SIGNAL          <1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..75
FT                   /id="PRO_0000001829"
FT   PEPTIDE         78..82
FT                   /note="Beta-bag cell peptide"
FT                   /id="PRO_0000001830"
FT   PEPTIDE         85..89
FT                   /note="Gamma-bag cell peptide"
FT                   /id="PRO_0000001831"
FT   PROPEP          92..130
FT                   /id="PRO_0000001832"
FT   PEPTIDE         132..140
FT                   /note="Alpha-bag cell peptide"
FT                   /id="PRO_0000001833"
FT   PROPEP          144..185
FT                   /id="PRO_0000001834"
FT   PEPTIDE         187..222
FT                   /note="Egg-laying hormone"
FT                   /id="PRO_0000001835"
FT   PEPTIDE         226..252
FT                   /note="Acidic peptide"
FT                   /id="PRO_0000001836"
FT   REGION          145..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         222
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:3734873"
FT   NON_TER         1
SQ   SEQUENCE   252 AA;  28499 MW;  4FADBB15D42DD6D2 CRC64;
     AISLLMCLIL SALCASSESA VVHGDDFAAE RAVKSSPYLV LSPADEMVGM STANEAFDKS
     PSYYDDDDDD FVNNEKRRLR FHKRRIRFHK RPQEVSGLKP VMMSRASASA DENSLFDLYN
     TDGAMYQREL RAPRLRFYSL RKRAAGDEDK AEEHNPETES HSRRKRSALT PSIRSLRSSL
     ESGIAKISIN QDLKAIADML IVEQKQEREK YLADLRQRLL NKGKRSSEVA LAASDKGDEE
     RELLNTLSNL LE