ID   ELHL_APLCA              Reviewed;         122 AA.
AC   P01361;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Atrial gland peptide B;
DE   AltName: Full=ELH-1L;
DE   Flags: Precursor;
OS   Aplysia californica (California sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6687446; DOI=10.1016/0092-8674(83)90492-0;
RA   Scheller R.H., Jackson J.F., McAllister L.B., Rothman B.S., Mayeri E.,
RA   Axel R.;
RT   "A single gene encodes multiple neuropeptides mediating a stereotyped
RT   behavior.";
RL   Cell 32:7-22(1983).
RN   [2]
RP   PROTEIN SEQUENCE OF 36-69, AND AMIDATION AT ILE-69.
RC   TISSUE=Bag cell;
RX   PubMed=6929554; DOI=10.1073/pnas.77.4.2328;
RA   Heller E., Kaczmarek L.K., Hunkapiller M.W., Hood L.E., Strumwasser F.;
RT   "Purification and primary structure of two neuroactive peptides that cause
RT   bag cell afterdischarge and egg-laying in Aplysia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:2328-2332(1980).
CC   -!- FUNCTION: The atrial gland peptide A and peptide B precursors are the
CC       source of the 2 peptides that, upon release from this reproductive
CC       system gland, initiate the egg-laying process by exciting the bag cell
CC       neurons. These neurons, clustered in neural connectives near the
CC       abdominal ganglion, in turn release other peptides that act directly on
CC       the ganglion and also, via the circulating hemolymph, on many other
CC       organs to control the physiological processes of egg-laying. One of
CC       these other peptides is the egg-laying hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the molluscan ELH family. {ECO:0000305}.
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DR   EMBL; J01018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A01631; GOGABA.
DR   AlphaFoldDB; P01361; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR003424; ELH.
DR   Pfam; PF02323; ELH; 2.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..34
FT                   /id="PRO_0000001810"
FT   PEPTIDE         36..69
FT                   /note="Atrial gland peptide B"
FT                   /id="PRO_0000001811"
FT   PROPEP          73..122
FT                   /id="PRO_0000001812"
FT   REGION          74..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         69
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:6929554"
SQ   SEQUENCE   122 AA;  13619 MW;  41E23272E67959FE CRC64;
     MKANTMFIIL CLTLSTLCVS SQFTSVLGKI FVTNRAVKSS SYEKYPFDLS KEDGAQPYFM
     TPRLRFYPIG KRAAGGMEQS EGQNPETKSH SWRERSVLTP SLLSLGESLE SGISKRISIN
     QD