ID   ELH_APLFA               Reviewed;          36 AA.
AC   Q7M427;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Egg-laying hormone;
DE            Short=ELH;
OS   Aplysia fasciata (Mottled sea hare) (Aplysia brasiliana).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=144767;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT LYS-36.
RC   TISSUE=Bag cell;
RX   PubMed=3226961; DOI=10.1016/0196-9781(88)90135-0;
RA   Nagle G.T., Painter S.D., Blankenship J.E., Choate J.V.A., Kurosky A.;
RT   "The bag cell egg-laying hormones of Aplysia brasiliana and Aplysia
RT   californica are identical.";
RL   Peptides 9:867-872(1988).
CC   -!- FUNCTION: ELH acts as a neurotransmitter locally, upon neurons of the
CC       abdominal ganglion and as a hormone by diffusing into the circulating
CC       hemolymph and modulating the activity of other organs. It specifically
CC       causes contraction of smooth muscle in the ovotestis and expulsion of
CC       the egg string.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Bag cell neurons.
CC   -!- SIMILARITY: Belongs to the molluscan ELH family. {ECO:0000305}.
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DR   PIR; A59064; A59064.
DR   AlphaFoldDB; Q7M427; -.
DR   SMR; Q7M427; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR003424; ELH.
DR   Pfam; PF02323; ELH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Egg-laying hormone"
FT                   /id="PRO_0000044635"
FT   MOD_RES         36
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:3226961"
SQ   SEQUENCE   36 AA;  4385 MW;  897CC74FD71F4C00 CRC64;
     ISINQDLKAI TDMLLTEQIR ERQRYLADLR QRLLEK