ID   ELH_THETS               Reviewed;          36 AA.
AC   P80594;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Egg-laying-like hormone;
DE   AltName: Full=L-ELH;
OS   Theromyzon tessulatum (Duck leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Theromyzon.
OX   NCBI_TaxID=13286;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT LYS-36, AND MASS SPECTROMETRY.
RC   TISSUE=CNS;
RX   PubMed=9387880; DOI=10.1016/s0169-328x(97)00145-9;
RA   Salzet M., Verger-Bocquet M., Vandenbulcke F., van Minnen J.;
RT   "Leech egg-laying-like hormone: structure, neuronal distribution and
RT   phylogeny.";
RL   Brain Res. Mol. Brain Res. 49:211-221(1997).
CC   -!- FUNCTION: May be involved in leech reproduction.
CC   -!- TISSUE SPECIFICITY: Supra, subesophageal ganglia and segmental ganglia
CC       of the ventral nerve cord and brain.
CC   -!- DEVELOPMENTAL STAGE: L-ELH greatly increases before egg-laying, while
CC       it strongly decreases after egg-laying.
CC   -!- MASS SPECTROMETRY: Mass=4172.29; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:9387880};
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DR   AlphaFoldDB; P80594; -.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide.
FT   PEPTIDE         1..36
FT                   /note="Egg-laying-like hormone"
FT                   /id="PRO_0000044774"
FT   MOD_RES         36
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:9387880"
SQ   SEQUENCE   36 AA;  4290 MW;  2633C40D6A15CECC CRC64;
     GSGVSNGGTE MIQLSHIRER QRYWAQDNLR RRFLEK