ELIC_DICCH
ID ELIC_DICCH Reviewed; 321 AA.
AC P0C7B7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Cys-loop ligand-gated ion channel;
DE AltName: Full=ELIC;
OS Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Dickeya.
OX NCBI_TaxID=556;
RN [1]
RP X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS), FUNCTION, AND SUBUNIT.
RX PubMed=18322461; DOI=10.1038/nature06717;
RA Hilf R.J., Dutzler R.;
RT "X-ray structure of a prokaryotic pentameric ligand-gated ion channel.";
RL Nature 452:375-379(2008).
CC -!- FUNCTION: Mediates cation-selective currents but does not discriminate
CC between different monovalent cations. {ECO:0000269|PubMed:18322461}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000269|PubMed:18322461}.
CC -!- INTERACTION:
CC P0C7B7; P0C7B7: -; NbExp=13; IntAct=EBI-15690068, EBI-15690068;
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000305}.
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DR PDB; 2VL0; X-ray; 3.30 A; A/B/C/D/E/F/G/H/I/J=1-321.
DR PDB; 2YKS; X-ray; 3.30 A; A/B/C/D/E/F/G/H/I/J=1-321.
DR PDB; 2YOE; X-ray; 3.90 A; A/B/C/D/E/F/G/H/I/J=11-316.
DR PDB; 3ZKR; X-ray; 3.65 A; A/B/C/D/E/F/G/H/I/J=11-316.
DR PDB; 4A97; X-ray; 3.34 A; A/B/C/D/E/F/G/H/I/J=11-316.
DR PDB; 4A98; X-ray; 3.61 A; A/B/C/D/E/F/G/H/I/J=11-316.
DR PDB; 4TWD; X-ray; 3.20 A; A/B/C/D/E/F/G/H/I/J=11-316.
DR PDB; 4TWF; X-ray; 3.90 A; A/B/C/D/E/F/G/H/I/J=11-316.
DR PDB; 4TWH; X-ray; 3.60 A; A/B/C/D/E/F/G/H/I/J=11-316.
DR PDB; 4YEU; X-ray; 4.60 A; A/B/C/D/E=11-199.
DR PDB; 5LID; X-ray; 4.50 A; A/B/C/D/E/F/G/H/I/J=11-316.
DR PDB; 5SXV; X-ray; 3.40 A; A/B/C/D/E/F/G/H/I/J=1-321.
DR PDB; 6HK0; X-ray; 3.45 A; A/B/C/D/E/F/G/H/I/J=11-316.
DR PDB; 6SSI; X-ray; 2.59 A; A/B/C/D/E=8-320.
DR PDB; 6SSP; X-ray; 3.25 A; A/B/C/D/E/F/G/H/I/J=8-320.
DR PDBsum; 2VL0; -.
DR PDBsum; 2YKS; -.
DR PDBsum; 2YOE; -.
DR PDBsum; 3ZKR; -.
DR PDBsum; 4A97; -.
DR PDBsum; 4A98; -.
DR PDBsum; 4TWD; -.
DR PDBsum; 4TWF; -.
DR PDBsum; 4TWH; -.
DR PDBsum; 4YEU; -.
DR PDBsum; 5LID; -.
DR PDBsum; 5SXV; -.
DR PDBsum; 6HK0; -.
DR PDBsum; 6SSI; -.
DR PDBsum; 6SSP; -.
DR AlphaFoldDB; P0C7B7; -.
DR SMR; P0C7B7; -.
DR DIP; DIP-58973N; -.
DR BindingDB; P0C7B7; -.
DR ChEMBL; CHEMBL4105825; -.
DR TCDB; 1.A.9.9.1; the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.
DR ABCD; P0C7B7; 3 sequenced antibodies.
DR EvolutionaryTrace; P0C7B7; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Ion channel;
KW Ion transport; Ligand-gated ion channel; Membrane; Receptor; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..321
FT /note="Cys-loop ligand-gated ion channel"
FT /id="PRO_0000330947"
FT TOPO_DOM 1..203
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..263
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 115..123
FT /note="Cys-loop"
FT STRAND 12..27
FT /evidence="ECO:0007829|PDB:6SSI"
FT TURN 28..31
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 32..44
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 51..53
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 56..59
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 61..68
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 86..94
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 98..111
FT /evidence="ECO:0007829|PDB:6SSI"
FT TURN 117..120
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 123..134
FT /evidence="ECO:0007829|PDB:6SSI"
FT TURN 137..139
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 140..148
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 155..157
FT /evidence="ECO:0007829|PDB:4TWD"
FT STRAND 159..162
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 166..173
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 178..180
FT /evidence="ECO:0007829|PDB:4A97"
FT STRAND 186..198
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 201..206
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 208..218
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 219..223
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 227..249
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 260..284
FT /evidence="ECO:0007829|PDB:6SSI"
FT STRAND 285..289
FT /evidence="ECO:0007829|PDB:4TWD"
FT HELIX 296..300
FT /evidence="ECO:0007829|PDB:6SSI"
FT HELIX 302..315
FT /evidence="ECO:0007829|PDB:6SSI"
SQ SEQUENCE 321 AA; 36808 MW; C532E1C4B657896D CRC64;
APADNAADAR PVDVSVSIFI NKIYGVNTLE QTYKVDGYIV AQWTGKPRKT PGDKPLIVEN
TQIERWINNG LWVPALEFIN VVGSPDTGNK RLMLFPDGRV IYNARFLGSF SNDMDFRLFP
FDRQQFVLEL EPFSYNNQQL RFSDIQVYTE NIDNEEIDEW WIRKASTHIS DIRYDHLSSV
QPNQNEFSRI TVRIDAVRNP SYYLWSFILP LGLIIAASWS VFWLESFSER LQTSFTLMLT
VVAYAFYTSN ILPRLPYTTV IDQMIIAGYG SIFAAILLII FAHHRQAMGV EDDLLIQRCR
LAFPLGFLAI GCVLVIRGIT L
