ELL3_BOVIN
ID ELL3_BOVIN Reviewed; 395 AA.
AC F1MGG3; Q2KI53;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=RNA polymerase II elongation factor ELL3;
GN Name=ELL3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Enhancer-binding elongation factor that specifically binds
CC enhancers in embryonic stem cells (ES cells), marks them, and is
CC required for their future activation during stem cell specification.
CC Elongation factor component of the super elongation complex (SEC), a
CC complex required to increase the catalytic rate of RNA polymerase II
CC transcription by suppressing transient pausing by the polymerase at
CC multiple sites along the DNA. Component of the little elongation
CC complex (LEC), a complex required to regulate small nuclear RNA (snRNA)
CC gene transcription by RNA polymerase II and III. Does not only bind to
CC enhancer regions of active genes, but also marks the enhancers that are
CC in a poised or inactive state in ES cells and is required for
CC establishing proper RNA polymerase II occupancy at developmentally
CC regulated genes in a cohesin-dependent manner. Probably required for
CC priming developmentally regulated genes for later recruitment of the
CC super elongation complex (SEC), for transcriptional activation during
CC differentiation. Required for recruitment of P-TEFb within SEC during
CC differentiation. Probably preloaded on germ cell chromatin, suggesting
CC that it may prime gene activation by marking enhancers as early as in
CC the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with AFF4. Component of the super elongation complex
CC (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or
CC AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Component of the
CC little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or
CC ELL3), ZC3H8, ICE1 and ICE2 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ELL/occludin family. {ECO:0000305}.
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DR EMBL; DAAA02052969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112766; AAI12767.1; -; mRNA.
DR RefSeq; NP_001039591.1; NM_001046126.2.
DR AlphaFoldDB; F1MGG3; -.
DR SMR; F1MGG3; -.
DR STRING; 9913.ENSBTAP00000022860; -.
DR PaxDb; F1MGG3; -.
DR PRIDE; F1MGG3; -.
DR GeneID; 512648; -.
DR KEGG; bta:512648; -.
DR CTD; 80237; -.
DR eggNOG; KOG4796; Eukaryota.
DR HOGENOM; CLU_692530_0_0_1; -.
DR InParanoid; F1MGG3; -.
DR OrthoDB; 335949at2759; -.
DR TreeFam; TF337345; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0008023; C:transcription elongation factor complex; ISS:UniProtKB.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; ISS:UniProtKB.
DR GO; GO:0042795; P:snRNA transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:InterPro.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR031175; ELL3.
DR InterPro; IPR019464; ELL_N.
DR InterPro; IPR010844; Occludin_ELL.
DR PANTHER; PTHR23288; PTHR23288; 1.
DR PANTHER; PTHR23288:SF18; PTHR23288:SF18; 1.
DR Pfam; PF10390; ELL; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..395
FT /note="RNA polymerase II elongation factor ELL3"
FT /id="PRO_0000421766"
FT DOMAIN 283..393
FT /note="OCEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01324"
FT REGION 124..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 113
FT /note="I -> N (in Ref. 2; AAI12767)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 395 AA; 44890 MW; 442C9D4F807F1BEF CRC64;
MEGPQELLSG KLRLCFTPAA RTSLLLLKLN DAALRALQEC HRQQVRPVIA FQGNRGYLRL
PGPHWSCLFS FIVSQCGQEG PGGPGLDLVC QCPGRSGPNR LHCLGPLRER LTIWAAMDSI
PAPSSLQRHN RTEDARDRES WQNVGDYPEA DTISQSQMGL EEVPDPLASS QGQSLPGSSR
EHMAQWEVRN QTLLPNRDPD QALPPSASQK HVDKKRPAPA AMVELKQKRL RTLAPSPLQG
LPSQDLQEED WEQEDKDEDM GPRLEHSPSV QADSESLSPE EVPDYLLQYR AIHSAEQQHA
YEQDFETDYA EYRILHARVA AASQRFIELA AEMNNVQRGT PEHKALEEKI VQEYKKFRKR
YPGYREEKRR CEYLHQKLSH IKGLILEFEE KNRGS
