ID   ELMD1_BOVIN             Reviewed;         326 AA.
AC   Q0IIE6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=ELMO domain-containing protein 1;
GN   Name=ELMOD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a GTPase-activating protein (GAP) toward guanine
CC       nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for
CC       GTPases outside the Arf family. {ECO:0000250}.
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DR   EMBL; BC122683; AAI22684.1; -; mRNA.
DR   RefSeq; NP_001071576.1; NM_001078108.1.
DR   AlphaFoldDB; Q0IIE6; -.
DR   SMR; Q0IIE6; -.
DR   STRING; 9913.ENSBTAP00000003485; -.
DR   PaxDb; Q0IIE6; -.
DR   PRIDE; Q0IIE6; -.
DR   Ensembl; ENSBTAT00000070105; ENSBTAP00000059345; ENSBTAG00000002691.
DR   GeneID; 768233; -.
DR   KEGG; bta:768233; -.
DR   CTD; 55531; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002691; -.
DR   VGNC; VGNC:28441; ELMOD1.
DR   eggNOG; KOG2998; Eukaryota.
DR   GeneTree; ENSGT00940000159782; -.
DR   HOGENOM; CLU_056289_0_0_1; -.
DR   InParanoid; Q0IIE6; -.
DR   OMA; KFSKTEW; -.
DR   OrthoDB; 1282549at2759; -.
DR   TreeFam; TF323472; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000002691; Expressed in occipital lobe and 76 other tissues.
DR   ExpressionAtlas; Q0IIE6; baseline and differential.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR030722; ELMOD1.
DR   PANTHER; PTHR12771:SF18; PTHR12771:SF18; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..326
FT                   /note="ELMO domain-containing protein 1"
FT                   /id="PRO_0000333276"
FT   DOMAIN          133..306
FT                   /note="ELMO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00664"
SQ   SEQUENCE   326 AA;  38036 MW;  4532DE5004A3616B CRC64;
     MKHFLRMLIQ VCLFFYCKFL WRCLKFVMRK LTGRCELQRI CYNTKPGASR TMKIETSLRD
     SKSKLLQTSV SVHPDAIEKT IDDIMELKKI NPDINPQLGI SLQACLLQIV GYRNLIADVE
     KLRRESYDSD NPQHEEMLLK LWKFLKPNTP LESRISKQWC EIGFQGDDPK TDFRGMGLLG
     LYNLQYFAER DAAAAQQVLS DSLHPKCSKF SKAEWEKKRM DKAIGYSFAI VGINITDLAY
     NLLVSGALKT HFYNIAPEAP TLSHFQQTFC YLMHEFHKFW IEEDPMDIME FNRVREKFRK
     RIIKQLQNPD MALCPHFAAS EGLINM