ID   ELMD1_MOUSE             Reviewed;         326 AA.
AC   Q3V1U8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=ELMO domain-containing protein 1;
GN   Name=Elmod1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Acts as a GTPase-activating protein (GAP) toward guanine
CC       nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for
CC       GTPases outside the Arf family. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE21051.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK132239; BAE21051.1; ALT_INIT; mRNA.
DR   CCDS; CCDS57678.1; -.
DR   RefSeq; NP_808437.2; NM_177769.4.
DR   AlphaFoldDB; Q3V1U8; -.
DR   SMR; Q3V1U8; -.
DR   BioGRID; 234774; 1.
DR   IntAct; Q3V1U8; 1.
DR   MINT; Q3V1U8; -.
DR   STRING; 10090.ENSMUSP00000046191; -.
DR   iPTMnet; Q3V1U8; -.
DR   PhosphoSitePlus; Q3V1U8; -.
DR   MaxQB; Q3V1U8; -.
DR   PaxDb; Q3V1U8; -.
DR   PRIDE; Q3V1U8; -.
DR   ProteomicsDB; 277819; -.
DR   Antibodypedia; 45528; 135 antibodies from 21 providers.
DR   DNASU; 270162; -.
DR   Ensembl; ENSMUST00000048409; ENSMUSP00000046191; ENSMUSG00000041986.
DR   GeneID; 270162; -.
DR   KEGG; mmu:270162; -.
DR   UCSC; uc009pmq.1; mouse.
DR   CTD; 55531; -.
DR   MGI; MGI:3583900; Elmod1.
DR   VEuPathDB; HostDB:ENSMUSG00000041986; -.
DR   eggNOG; KOG2998; Eukaryota.
DR   GeneTree; ENSGT00940000159782; -.
DR   HOGENOM; CLU_056289_0_0_1; -.
DR   InParanoid; Q3V1U8; -.
DR   OMA; KFSKTEW; -.
DR   OrthoDB; 1282549at2759; -.
DR   PhylomeDB; Q3V1U8; -.
DR   TreeFam; TF323472; -.
DR   BioGRID-ORCS; 270162; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Elmod1; mouse.
DR   PRO; PR:Q3V1U8; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q3V1U8; protein.
DR   Bgee; ENSMUSG00000041986; Expressed in dorsal striatum and 142 other tissues.
DR   ExpressionAtlas; Q3V1U8; baseline and differential.
DR   Genevisible; Q3V1U8; MM.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR030722; ELMOD1.
DR   PANTHER; PTHR12771:SF18; PTHR12771:SF18; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   1: Evidence at protein level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..326
FT                   /note="ELMO domain-containing protein 1"
FT                   /id="PRO_0000225015"
FT   DOMAIN          133..306
FT                   /note="ELMO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00664"
SQ   SEQUENCE   326 AA;  38034 MW;  25195ABAE69CBD75 CRC64;
     MKHFLRMLIQ VCLYFYCKFL WRCMKFVMRK LTGRCELQRI CYGTKPGASR TMKIETSLRD
     SKSKLLQTSV SVHPDAIEKT IDDIMELKKI NPDINPQLGI SLQACLLQIV GYRNLIADVE
     KLRREPYDSD NPQHEEMLLK LWELLKPNTP LESRVSKQWC EIGFQGDDPK TDFRGMGLLG
     LYNLQYFAER DATVAQQVLS DSVHPKCSKF SKIEWEKKKM DKAIGYSFAI VGINITDLAY
     NLLVSGALKT HFYNIAPEAP TLSHFQQTFC YLMHEFHKFW IEEDPMDIME FNRVREKFRK
     RIIKQLQNPD MALCPHFAAS EGLINM