ID   ELMD1_PONAB             Reviewed;         326 AA.
AC   Q5NVD7;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=ELMO domain-containing protein 1;
GN   Name=ELMOD1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a GTPase-activating protein (GAP) toward guanine
CC       nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for
CC       GTPases outside the Arf family. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR926100; CAI29726.1; -; mRNA.
DR   RefSeq; NP_001127118.1; NM_001133646.1.
DR   AlphaFoldDB; Q5NVD7; -.
DR   STRING; 9601.ENSPPYP00000004390; -.
DR   Ensembl; ENSPPYT00000047874; ENSPPYP00000027932; ENSPPYG00000003835.
DR   GeneID; 100174164; -.
DR   KEGG; pon:100174164; -.
DR   CTD; 55531; -.
DR   eggNOG; KOG2998; Eukaryota.
DR   GeneTree; ENSGT00940000159782; -.
DR   InParanoid; Q5NVD7; -.
DR   OrthoDB; 1282549at2759; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR030722; ELMOD1.
DR   PANTHER; PTHR12771:SF18; PTHR12771:SF18; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..326
FT                   /note="ELMO domain-containing protein 1"
FT                   /id="PRO_0000225016"
FT   DOMAIN          133..306
FT                   /note="ELMO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00664"
SQ   SEQUENCE   326 AA;  38092 MW;  9DA36B93D9B25551 CRC64;
     MKHFLRMLIQ VCLYFYCKFL WRCLKFVMRK LTGRCELQRI CYNTKPGASR TMKIETSLRD
     SKSKLLQTSV SVHPDAIEKT IEDIMELKKI NPDVNPQLGI SLQACLLQIV GYRNLIADVE
     KLRREPYDSD NPQHEEMLLK LWKFLKPNTP LESRISKQWC EIGFQGDDPK TDFRGMGLLG
     LYNLQYFAER DATAAQQVLS DSLHPKCSKF SKAEWEKKRM DKAIGYSFAI VGINITDLAY
     NLLVSGALKT HFYNIAPEAP TLSHFQQTFC YLMHEFHKFW IEEDPMDIME FNRVREKFRK
     RIIKQLQNPD MALCPHFAAS EGLINM