ID   ELMD2_BOVIN             Reviewed;         293 AA.
AC   Q08DZ3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=ELMO domain-containing protein 2;
GN   Name=ELMOD2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=17452337; DOI=10.1074/jbc.m701347200;
RA   Bowzard J.B., Cheng D., Peng J., Kahn R.A.;
RT   "ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.";
RL   J. Biol. Chem. 282:17568-17580(2007).
CC   -!- FUNCTION: Acts as a GTPase-activating protein (GAP) toward guanine
CC       nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for
CC       GTPases outside the Arf family.
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DR   EMBL; BC123498; AAI23499.1; -; mRNA.
DR   RefSeq; NP_001069173.1; NM_001075705.1.
DR   RefSeq; XP_005217611.1; XM_005217554.3.
DR   AlphaFoldDB; Q08DZ3; -.
DR   SMR; Q08DZ3; -.
DR   STRING; 9913.ENSBTAP00000018612; -.
DR   PaxDb; Q08DZ3; -.
DR   PRIDE; Q08DZ3; -.
DR   Ensembl; ENSBTAT00000018612; ENSBTAP00000018612; ENSBTAG00000014007.
DR   GeneID; 515278; -.
DR   KEGG; bta:515278; -.
DR   CTD; 255520; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014007; -.
DR   VGNC; VGNC:28442; ELMOD2.
DR   eggNOG; KOG2998; Eukaryota.
DR   GeneTree; ENSGT00940000156589; -.
DR   HOGENOM; CLU_056289_0_0_1; -.
DR   InParanoid; Q08DZ3; -.
DR   OMA; FRFWLKW; -.
DR   OrthoDB; 1282549at2759; -.
DR   TreeFam; TF323472; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000014007; Expressed in semen and 108 other tissues.
DR   ExpressionAtlas; Q08DZ3; baseline and differential.
DR   GO; GO:0032991; C:protein-containing complex; IDA:AgBase.
DR   GO; GO:0005096; F:GTPase activator activity; IDA:AgBase.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   GO; GO:0050688; P:regulation of defense response to virus; ISS:UniProtKB.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR030724; ELMOD2.
DR   PANTHER; PTHR12771:SF47; PTHR12771:SF47; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; GTPase activation; Reference proteome.
FT   CHAIN           1..293
FT                   /note="ELMO domain-containing protein 2"
FT                   /id="PRO_0000333277"
FT   DOMAIN          126..282
FT                   /note="ELMO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00664"
SQ   SEQUENCE   293 AA;  34831 MW;  D88AC33F603F4521 CRC64;
     MFIALWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS LTYSKNKVLQ
     KATLVVQSEV DRCVEDIMKE KNINPEKDAS FKICMKACLL QISGYKQLYL DVESVRKKPY
     DSDNLQHEKL LIKLWNLLMP TKKLKARISK QWADIGFQGD DPKTDFRGMG ILGLINLVYF
     SENYTSEAHQ ILSRSNHPKL GYSYAIVGIN LTEMAYSLLK SEALKFHLYN FVPGIPTMEH
     FHQFYCYLVY EFDKFWFEEK PESIMYFNVY REKFHEKIKG LLLDCNVSLT LKI