ID   ELMD2_MOUSE             Reviewed;         293 AA.
AC   Q8BGF6; Q6AXC7; Q8BHP5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=ELMO domain-containing protein 2;
GN   Name=Elmod2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Aorta, Bone, Lung, and Skin;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, and Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Acts as a GTPase-activating protein (GAP) toward guanine
CC       nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for
CC       GTPases outside the Arf family.
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DR   EMBL; AK029044; BAC26262.1; -; mRNA.
DR   EMBL; AK036746; BAC29561.1; -; mRNA.
DR   EMBL; AK041137; BAC30834.1; -; mRNA.
DR   EMBL; AK084950; BAC39319.1; -; mRNA.
DR   EMBL; BC079654; AAH79654.1; -; mRNA.
DR   CCDS; CCDS22450.1; -.
DR   RefSeq; NP_001164162.1; NM_001170691.1.
DR   RefSeq; NP_848851.3; NM_178736.5.
DR   RefSeq; XP_006531042.1; XM_006530979.2.
DR   AlphaFoldDB; Q8BGF6; -.
DR   SMR; Q8BGF6; -.
DR   STRING; 10090.ENSMUSP00000052287; -.
DR   iPTMnet; Q8BGF6; -.
DR   PhosphoSitePlus; Q8BGF6; -.
DR   SwissPalm; Q8BGF6; -.
DR   EPD; Q8BGF6; -.
DR   MaxQB; Q8BGF6; -.
DR   PaxDb; Q8BGF6; -.
DR   PeptideAtlas; Q8BGF6; -.
DR   PRIDE; Q8BGF6; -.
DR   ProteomicsDB; 277783; -.
DR   Antibodypedia; 45421; 169 antibodies from 23 providers.
DR   Ensembl; ENSMUST00000053902; ENSMUSP00000052287; ENSMUSG00000035151.
DR   Ensembl; ENSMUST00000177594; ENSMUSP00000137044; ENSMUSG00000035151.
DR   GeneID; 244548; -.
DR   KEGG; mmu:244548; -.
DR   UCSC; uc009mjz.2; mouse.
DR   CTD; 255520; -.
DR   MGI; MGI:2445165; Elmod2.
DR   VEuPathDB; HostDB:ENSMUSG00000035151; -.
DR   eggNOG; KOG2998; Eukaryota.
DR   GeneTree; ENSGT00940000156589; -.
DR   HOGENOM; CLU_056289_0_0_1; -.
DR   InParanoid; Q8BGF6; -.
DR   OMA; FRFWLKW; -.
DR   OrthoDB; 1282549at2759; -.
DR   PhylomeDB; Q8BGF6; -.
DR   TreeFam; TF323472; -.
DR   BioGRID-ORCS; 244548; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Elmod2; mouse.
DR   PRO; PR:Q8BGF6; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q8BGF6; protein.
DR   Bgee; ENSMUSG00000035151; Expressed in primary oocyte and 227 other tissues.
DR   ExpressionAtlas; Q8BGF6; baseline and differential.
DR   Genevisible; Q8BGF6; MM.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   GO; GO:0050688; P:regulation of defense response to virus; ISS:UniProtKB.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR030724; ELMOD2.
DR   PANTHER; PTHR12771:SF47; PTHR12771:SF47; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   1: Evidence at protein level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..293
FT                   /note="ELMO domain-containing protein 2"
FT                   /id="PRO_0000225018"
FT   DOMAIN          126..282
FT                   /note="ELMO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00664"
FT   CONFLICT        47
FT                   /note="I -> T (in Ref. 2; AAH79654)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        222
FT                   /note="E -> G (in Ref. 1; BAC29561)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   293 AA;  34747 MW;  9DA5E0665FF9012C CRC64;
     MFVSLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYGG AQRTYRIENS LTYSKNKVLQ
     NATRVAQSEL DRCIANIMKE KNICSEKDTS FQICMRTCLL QITGYKQLYH DVENVRKKPY
     DSANAQHEKM LLKLWSLLMP TKKLTARISK QWADIGFQGD DPKTDFRGMG ILGLINLVYF
     SENYTSEAHQ ILSRSNHPKL GYSYAIVGIN LTEMAYSLLK SEALKLHLYN FVPGVPTMEH
     FHQFYCYLVY EFDKFWLEEE PESIMYFNLY REKFHERIKG LLMDCNAVLT LKT