ID   ELMD3_BOVIN             Reviewed;         381 AA.
AC   Q58DT5; Q0V8F5; Q58CP6;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=ELMO domain-containing protein 3;
DE   AltName: Full=RNA-binding motif and ELMO domain-containing protein 1;
GN   Name=ELMOD3; Synonyms=RBED1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Acts as a GTPase-activating protein (GAP) for ARL2 with low
CC       specific activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250}. Cell
CC       projection, kinocilium {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Note=Also present in the cuticular plate of auditory
CC       hair cells. Expressed along the length of the stereocilia, but excluded
CC       from the very tip. Colocalizes with F-actin cytoskeleton (By
CC       similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q58DT5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q58DT5-2; Sequence=VSP_022915, VSP_022916;
CC       Name=3;
CC         IsoId=Q58DT5-3; Sequence=VSP_022914, VSP_022915, VSP_022916;
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DR   EMBL; BT021512; AAX46359.1; -; mRNA.
DR   EMBL; BT021901; AAX46748.1; -; mRNA.
DR   EMBL; BT026263; ABG67102.1; -; mRNA.
DR   AlphaFoldDB; Q58DT5; -.
DR   STRING; 9913.ENSBTAP00000032975; -.
DR   PaxDb; Q58DT5; -.
DR   Ensembl; ENSBTAT00000054220; ENSBTAP00000049817; ENSBTAG00000021935. [Q58DT5-3]
DR   VEuPathDB; HostDB:ENSBTAG00000021935; -.
DR   eggNOG; KOG2998; Eukaryota.
DR   GeneTree; ENSGT00390000009488; -.
DR   InParanoid; Q58DT5; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000021935; Expressed in granulosa cell and 111 other tissues.
DR   ExpressionAtlas; Q58DT5; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0060091; C:kinocilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR030731; ELMOD3.
DR   PANTHER; PTHR12771:SF2; PTHR12771:SF2; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..381
FT                   /note="ELMO domain-containing protein 3"
FT                   /id="PRO_0000274902"
FT   DOMAIN          170..324
FT                   /note="ELMO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00664"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..17
FT                   /note="MNENFHSFHEKELRDGQ -> MVLPRFLIFDNK (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_022914"
FT   VAR_SEQ         247
FT                   /note="Q -> P (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_022915"
FT   VAR_SEQ         248..381
FT                   /note="Missing (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_022916"
SQ   SEQUENCE   381 AA;  42632 MW;  1E97C55868BCEF10 CRC64;
     MNENFHSFHE KELRDGQVES VSAGSSPPCD KDSSALLAFR GISISELKNH SVLQALTAEA
     NAWEPRVVST EVLQAQEEWE AVESIHPETG SRASMDQPGQ LISFSEALQH FQTVDLSSFK
     KRIQPTIRRT GLAALRHYLF GPPKLHQGLR EERDLVLTIA QCGLDSQDPM HGRVLQTIYK
     KLTGSKFDCA LHGDHWEDLG FQGTNPATDL RGAGFLALLH LLYLVMDSKT LLMAREILRL
     SRHHIQQFPF CLMSVNITRI AIQALREECL SRECNRQQKV IPVVNSFYAA TFLRLAHIWR
     TQHKTISDSG FVLKDLEMSA KKSPRRLLKT LETYLAGVSK GQASLLGTQK CSGPQAPHSK
     DLTFTGVCDL PSHLSEGTWL I