ID   ELMD3_RAT               Reviewed;         356 AA.
AC   Q5XIQ2;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=ELMO domain-containing protein 3;
DE   AltName: Full=RNA-binding motif and ELMO domain-containing protein 1;
GN   Name=Elmod3; Synonyms=Rbed1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Brown Norway; TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=24039609; DOI=10.1371/journal.pgen.1003774;
RA   Jaworek T.J., Richard E.M., Ivanova A.A., Giese A.P., Choo D.I., Khan S.N.,
RA   Riazuddin S., Kahn R.A., Riazuddin S.;
RT   "An alteration in ELMOD3, an Arl2 GTPase-activating protein, is associated
RT   with hearing impairment in humans.";
RL   PLoS Genet. 9:E1003774-E1003774(2013).
CC   -!- FUNCTION: Acts as a GTPase-activating protein (GAP) for ARL2 with low
CC       specific activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC       {ECO:0000269|PubMed:24039609}. Cell projection, kinocilium
CC       {ECO:0000269|PubMed:24039609}. Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:24039609}. Note=Also present in the cuticular plate
CC       of auditory hair cells. In the organ of Corti, in inner hair cells,
CC       expressed along the length of the stereocilia, but excluded from the
CC       very tip. Colocalizes with F-actin cytoskeleton.
CC   -!- TISSUE SPECIFICITY: Expressed in the cochlea and in the organ of Corti,
CC       as well as in the supporting cells, including pillar and Dieters' cells
CC       (at protein level). {ECO:0000269|PubMed:24039609}.
CC   -!- DEVELOPMENTAL STAGE: At P02, in the organ of Corti, expressed in the
CC       stereocilia of outer hair cells and in the kinocilia of both outer and
CC       inner hair cells. Also concentrated at the cuticular plate level of
CC       auditory hair cells. However, before P07, expression in the inner hair
CC       cell stereocilia is very weak. By P07, in auditory hair cells, patchy
CC       expression detected along the length of stereocilia, but absent from
CC       the very tip. Later in development, detected in the stereocilia bundles
CC       and microvilli of sensory cells and also in the supporting cell bodies
CC       (at protein level).
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DR   EMBL; BC083623; AAH83623.1; -; mRNA.
DR   RefSeq; NP_001013105.1; NM_001013087.1.
DR   AlphaFoldDB; Q5XIQ2; -.
DR   SMR; Q5XIQ2; -.
DR   STRING; 10116.ENSRNOP00000054799; -.
DR   PaxDb; Q5XIQ2; -.
DR   PRIDE; Q5XIQ2; -.
DR   Ensembl; ENSRNOT00000057989; ENSRNOP00000054799; ENSRNOG00000038102.
DR   GeneID; 297342; -.
DR   KEGG; rno:297342; -.
DR   UCSC; RGD:1306408; rat.
DR   CTD; 84173; -.
DR   RGD; 1306408; Elmod3.
DR   eggNOG; KOG2998; Eukaryota.
DR   GeneTree; ENSGT00390000009488; -.
DR   InParanoid; Q5XIQ2; -.
DR   PhylomeDB; Q5XIQ2; -.
DR   PRO; PR:Q5XIQ2; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000038102; Expressed in testis and 18 other tissues.
DR   ExpressionAtlas; Q5XIQ2; baseline and differential.
DR   Genevisible; Q5XIQ2; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0060091; C:kinocilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR030731; ELMOD3.
DR   PANTHER; PTHR12771:SF2; PTHR12771:SF2; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; GTPase activation;
KW   Reference proteome.
FT   CHAIN           1..356
FT                   /note="ELMO domain-containing protein 3"
FT                   /id="PRO_0000274905"
FT   DOMAIN          170..324
FT                   /note="ELMO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00664"
SQ   SEQUENCE   356 AA;  40014 MW;  F6110762B75E4EBF CRC64;
     MSETSCSFLI EKEFQDGQVE SVSAGLSPSY KDNGALMAFR GIPISELKNH GILQVLTAET
     NGWQPGVVSA EMLRAQEEWE VVDTIHPDIE SGVSSQQPGQ FISFNEALEH FQTVDLSSFK
     KRIQPTIQRT GLAALRHCLF GPPKLHQGLQ EERDLVLTIA QCGLDSQNPT HGRVLQTIYK
     KLTGSKFDCA LHGDHWEDLG FQGANPATDL RGTGFLALLH LLYLVMDSKT LLMAQEILRL
     SHHHIQQFPF CLMSVNITRI AIQALREECL SRECNRRRKV IPVVNSFYAA TFLHLARMWR
     TQHNTILDSG FVLKELGIEP RALRSIGKRS TAELNPQPAP AFLVWDYSRA FMHGSR