ELMOE_DICDI
ID ELMOE_DICDI Reviewed; 1677 AA.
AC Q54WH5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=ELMO domain-containing protein E;
GN Name=elmoE; ORFNames=DDB_G0279657;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
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DR EMBL; AAFI02000032; EAL67603.1; -; Genomic_DNA.
DR RefSeq; XP_641578.1; XM_636486.1.
DR AlphaFoldDB; Q54WH5; -.
DR SMR; Q54WH5; -.
DR STRING; 44689.DDB0233920; -.
DR PaxDb; Q54WH5; -.
DR EnsemblProtists; EAL67603; EAL67603; DDB_G0279657.
DR GeneID; 8622153; -.
DR KEGG; ddi:DDB_G0279657; -.
DR dictyBase; DDB_G0279657; elmoE.
DR eggNOG; ENOG502RE9F; Eukaryota.
DR HOGENOM; CLU_241621_0_0_1; -.
DR InParanoid; Q54WH5; -.
DR OMA; HVFFGEW; -.
DR Reactome; R-DDI-8849471; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
DR PRO; PR:Q54WH5; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0031252; C:cell leading edge; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0044354; C:macropinosome; IDA:dictyBase.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IPI:dictyBase.
DR GO; GO:0031267; F:small GTPase binding; IPI:dictyBase.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030041; P:actin filament polymerization; IMP:dictyBase.
DR GO; GO:0048870; P:cell motility; IBA:GO_Central.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:1903013; P:response to differentiation-inducing factor 1; HDA:dictyBase.
DR InterPro; IPR006816; ELMO_dom.
DR Pfam; PF04727; ELMO_CED12; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Coiled coil; Reference proteome.
FT CHAIN 1..1677
FT /note="ELMO domain-containing protein E"
FT /id="PRO_0000333282"
FT DOMAIN 492..710
FT /note="ELMO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00664"
FT REGION 112..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1261..1404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1434..1454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1467..1593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1654..1677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1186..1212
FT /evidence="ECO:0000255"
FT COMPBIAS 264..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1501..1580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1660..1677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1677 AA; 186261 MW; 36DA15F289BCAA3E CRC64;
MKLQIYNPNG EEFQYDFKSD IPFSFHIKNL YENLVVHNNG LKKILQSFPY CEANRSYDEI
YSHYSLQEAT SGNWMSNSTD STFIKGSPDN TLFFKLKPLT HYLTPIEKLI GTTTSSSSSS
SSPSSSSSSS SSSSSSSPSS PSLIGLILSL QTHLALLMYE NIYGNKNNSK DTNNSGTINN
NNNNNNNSGG SNIKLSSTPS SSFLTFPTST SNLLLSSDVI KKILNIVFLA PSPQSLQLLV
FLVSNSPSND DLLSQISNTH SNSQLHGFSI GGGGGGSGNN SSITSIGGGD SKKIENKDNS
GSAVVGSQSN SPQSSSFVKS QQIQQQQQYQ KPNNSSPPPT TTTTTTTTTT TSGSQVKLSV
GGNSGSFNNT TESSPSLFTL VDTAIKSVST EHSSNFYLHI LNNPAYNEVI ETHFEMVCLI
LSLINNMYRL SPNPINYFNR LHNDSILKYI MEFAKKNQKI YQNTQYIVLR NYLMKELHMQ
RLHPINVDKV LSHQILLSDL WGSALSSYPF GGINSEHWLL LGFRSSNPME DFKNTGVLAL
RNLSYFSKQH LQPFQSLLLT QTKREKDDND NNNNKVIDKP IITNKFNIET LDDDNDNNNN
QELNNNNNNN NNNNYNIKTK PRSNSRSYPL ATVAISLTYT LSNIFRIGRI NDSPIDSSIW
DIAFSGSNWF DEIFVTTFNL FESLWHSEAH SYSDFPQVIS HTREIIEKVC SKSPINLQDF
KDKLTTLLEK KDEISSLDVN TVETLARYHQ LQPSHINKRH IHKFFGERVN VDKLPNSNNP
TDNIITTNTN TTTTTTTSTN NDCESTILQD HIESDKNNDD NNNNNEIIDD CESNSSFLVS
SNTKEFSGKN LIKFFGEKTD QKEQYSTQPS NVKSYKLKNF FGDQPVVINK NGGGGGGGGG
GGVDNELNQG GETVNKNKND LIDDSDDEND NDEVNNNNNS NRINQDINHK LYGNSPISER
NHRLHVFFGE WFDTEQVEYN EKIRSSSSTP DTSSPPLNSQ PESARLHKLN KFFGERVNIP
ISKPKVIGEG GGGGIFPIDD IDVTDGSTNN HHIGGGGGGG SSDNLLSRSP EETRSDFKAQ
KVLGERLDIK KEKESINFAS QPSNVREYKL HKLFGEMVPA HKQKSPKLQG GSGPWKKGNV
SKSDSQAVVA PLNTIKFNNG NTNMNPLLQS CPTPINSPTS LSSDHLLDDV LDLNQTNNNI
DNENDDINEA IIPPSLSPTL LGVNNHGEEE EEEEEEEEGY NHTQDNHAQD NHAQDNLLLL
DDDDDTKSEP IPSTNTLLDS DIIPNNTTTT TTTTTTTTTT TTNTTGQKRI SILSTDTNRP
GSSNYGESSL SNGSRFDGIP ESTTHNANGD DDHQINLHSS SPQPLPKFVN TDDEDNNNNN
NNKKQDDDED DEDDDDKEEI RKKRENKTNH RLHVFFGERF DVENIHFFTR VSSSPGSYDA
HLNNPHLSVS PQPETVRSYK LKKFFGKNPE DNVTLSSSYD SSTSPLLSQL NHHHHHNHHQ
SASNLINNIN NNNNNNNNNN SNNNSNNQNN LNSSNNSNNS SISNNSGKNN TNNNNNNNTN
NNNDNSPSTS PSSSFKKHQY QYVSAEDPEG DVSKTNEIRK LRRDFKTQRI LGERLNIKKE
STVVAFQDQP STIKVDKLIS LFGEKVGFSL KRKESQRDLQ HQASSSNLKF SLASSSK
