ID   ELO4_CAEEL              Reviewed;         291 AA.
AC   Q03574;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Putative fatty acid elongation protein 4;
DE            EC=2.3.1.199;
DE   AltName: Full=3-keto acyl-CoA synthase elo-4;
DE   AltName: Full=Very-long-chain 3-oxoacyl-CoA synthase 4;
GN   Name=elo-4; ORFNames=C40H1.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Could be implicated in synthesis of very long chain fatty
CC       acids. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC         chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC         EC=2.3.1.199;
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ELO family. {ECO:0000305}.
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DR   EMBL; Z19154; CAA79555.1; -; Genomic_DNA.
DR   PIR; S28299; S28299.
DR   RefSeq; NP_499056.1; NM_066655.3.
DR   AlphaFoldDB; Q03574; -.
DR   SMR; Q03574; -.
DR   BioGRID; 48196; 1.
DR   STRING; 6239.C40H1.4; -.
DR   PaxDb; Q03574; -.
DR   EnsemblMetazoa; C40H1.4.1; C40H1.4.1; WBGene00001242.
DR   GeneID; 183367; -.
DR   KEGG; cel:CELE_C40H1.4; -.
DR   UCSC; C40H1.4; c. elegans.
DR   CTD; 183367; -.
DR   WormBase; C40H1.4; CE00112; WBGene00001242; elo-4.
DR   eggNOG; KOG3072; Eukaryota.
DR   GeneTree; ENSGT01050000244965; -.
DR   HOGENOM; CLU_048483_1_2_1; -.
DR   InParanoid; Q03574; -.
DR   OMA; FYILMNY; -.
DR   OrthoDB; 1094172at2759; -.
DR   PhylomeDB; Q03574; -.
DR   Reactome; R-CEL-75876; Synthesis of very long-chain fatty acyl-CoAs.
DR   UniPathway; UPA00094; -.
DR   PRO; PR:Q03574; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00001242; Expressed in embryo and 3 other tissues.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0009922; F:fatty acid elongase activity; IBA:GO_Central.
DR   GO; GO:0102756; F:very-long-chain 3-ketoacyl-CoA synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0034625; P:fatty acid elongation, monounsaturated fatty acid; IBA:GO_Central.
DR   GO; GO:0034626; P:fatty acid elongation, polyunsaturated fatty acid; IBA:GO_Central.
DR   GO; GO:0019367; P:fatty acid elongation, saturated fatty acid; IBA:GO_Central.
DR   GO; GO:0030148; P:sphingolipid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0042761; P:very long-chain fatty acid biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR030457; ELO_CS.
DR   InterPro; IPR002076; ELO_fam.
DR   PANTHER; PTHR11157; PTHR11157; 1.
DR   Pfam; PF01151; ELO; 1.
DR   PROSITE; PS01188; ELO; 1.
PE   3: Inferred from homology;
KW   Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..291
FT                   /note="Putative fatty acid elongation protein 4"
FT                   /id="PRO_0000207547"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   291 AA;  34059 MW;  66572272A53E343F CRC64;
     MELAEFWNDL NTFTIYGPNH TDMTTKYKYS YHFPGEQVAD PQYWTILFQK YWYHSITISV
     LYFILIKVIQ KFMENRKPFT LKYPLILWNG ALAAFSIIAT LRFSIDPLRS LYAEGFYKTL
     CYSCNPTDVA AFWSFAFALS KIVELGDTMF IILRKRPLIF LHYYHHAAVL IYTVHSGAEH
     TAAGRFYILM NYFAHSLMYT YYTVSAMGYR LPKWVSMTVT TVQTTQMLAG VGITWMVYKV
     KTEYKLPCQQ SVANLYLAFV IYVTFAILFI QFFVKAYIIK SSKKSKSVKN E