ID   ELOC_DICDI              Reviewed;         109 AA.
AC   Q54Q05;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Elongin-C;
DE   AltName: Full=RNA polymerase II transcription factor SIII subunit C;
DE   AltName: Full=Transcription elongation factor B polypeptide 1;
GN   Name=tceb1; ORFNames=DDB_G0284201;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: SIII, also known as elongin, is a general transcription
CC       elongation factor that increases the RNA polymerase II transcription
CC       elongation past template-encoded arresting sites. Subunit A is
CC       transcriptionally active and its transcription activity is strongly
CC       enhanced by binding to the dimeric complex of the SIII regulatory
CC       subunits B and C (elongin BC complex) (By similarity).
CC       {ECO:0000250|UniProtKB:Q15369}.
CC   -!- FUNCTION: The elongin BC complex seems to be involved as an adapter
CC       protein in the proteasomal degradation of target proteins via different
CC       E3 ubiquitin ligase complexes. {ECO:0000250|UniProtKB:Q15369}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000064; EAL65289.1; -; Genomic_DNA.
DR   RefSeq; XP_638640.1; XM_633548.1.
DR   AlphaFoldDB; Q54Q05; -.
DR   SMR; Q54Q05; -.
DR   STRING; 44689.DDB0238113; -.
DR   PaxDb; Q54Q05; -.
DR   EnsemblProtists; EAL65289; EAL65289; DDB_G0284201.
DR   GeneID; 8624471; -.
DR   KEGG; ddi:DDB_G0284201; -.
DR   dictyBase; DDB_G0284201; -.
DR   eggNOG; KOG3473; Eukaryota.
DR   HOGENOM; CLU_130038_3_0_1; -.
DR   InParanoid; Q54Q05; -.
DR   OMA; VCEYLYY; -.
DR   PhylomeDB; Q54Q05; -.
DR   Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-DDI-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-DDI-75955; RNA Polymerase II Transcription Elongation.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q54Q05; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0070449; C:elongin complex; IBA:GO_Central.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR039948; ELC1.
DR   InterPro; IPR001232; SKP1-like.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR016073; Skp1_comp_POZ.
DR   PANTHER; PTHR20648; PTHR20648; 1.
DR   Pfam; PF03931; Skp1_POZ; 1.
DR   SMART; SM00512; Skp1; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation pathway.
FT   CHAIN           1..109
FT                   /note="Elongin-C"
FT                   /id="PRO_0000333269"
SQ   SEQUENCE   109 AA;  12576 MW;  AD48F30DBBD33E86 CRC64;
     MSDNPDTHDL NSDVLRLYSS TGHEFVLSRK MSYVSGTIKS MLSGDNSNFM EDQNNEIRFR
     EISTPVLEKV IQYFYFKNKY TNSTTDLPEF PINEKVVVDL LLAAHFLDT