ID   ELOC_SCHPO              Reviewed;          97 AA.
AC   Q9USX9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Elongin-C;
GN   Name=elc1 {ECO:0000250|UniProtKB:Q03071}; ORFNames=SPBC1861.07;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAB52743.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Prevents degradation of interacting proteins by the
CC       proteasome. {ECO:0000250|UniProtKB:Q03071}.
CC   -!- SUBUNIT: Forms a complex with protein pof4/ela1.
CC       {ECO:0000250|UniProtKB:Q03071}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000255}.
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DR   EMBL; CU329671; CAB52743.1; -; Genomic_DNA.
DR   PIR; T39746; T39746.
DR   RefSeq; NP_596724.1; NM_001022649.1.
DR   AlphaFoldDB; Q9USX9; -.
DR   SMR; Q9USX9; -.
DR   BioGRID; 276267; 194.
DR   STRING; 4896.SPBC1861.07.1; -.
DR   MaxQB; Q9USX9; -.
DR   PaxDb; Q9USX9; -.
DR   EnsemblFungi; SPBC1861.07.1; SPBC1861.07.1:pep; SPBC1861.07.
DR   GeneID; 2539714; -.
DR   KEGG; spo:SPBC1861.07; -.
DR   PomBase; SPBC1861.07; -.
DR   VEuPathDB; FungiDB:SPBC1861.07; -.
DR   eggNOG; KOG3473; Eukaryota.
DR   HOGENOM; CLU_130038_1_1_1; -.
DR   InParanoid; Q9USX9; -.
DR   OMA; VCEYLYY; -.
DR   PhylomeDB; Q9USX9; -.
DR   Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-SPO-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-SPO-75955; RNA Polymerase II Transcription Elongation.
DR   Reactome; R-SPO-8951664; Neddylation.
DR   Reactome; R-SPO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q9USX9; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0070449; C:elongin complex; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IC:PomBase.
DR   GO; GO:0003711; F:transcription elongation regulator activity; IC:PomBase.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IC:PomBase.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IC:PomBase.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR039948; ELC1.
DR   InterPro; IPR001232; SKP1-like.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR016073; Skp1_comp_POZ.
DR   PANTHER; PTHR20648; PTHR20648; 1.
DR   Pfam; PF03931; Skp1_POZ; 1.
DR   SMART; SM00512; Skp1; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..97
FT                   /note="Elongin-C"
FT                   /id="PRO_0000319984"
SQ   SEQUENCE   97 AA;  11268 MW;  1B3D325A739D1F75 CRC64;
     MEKEYVRLIS GDGFVFILEK EIACLSGTIR AILNEGIFSE AQKNECTFPD IRATLLEKVC
     EYLHYNYRYK NQLDIPKFDI PPEMVLELLV TAEYLEA