ID   ELOF1_HUMAN             Reviewed;          83 AA.
AC   P60002; Q8R1J7; Q96II4;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2003, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Transcription elongation factor 1 homolog;
GN   Name=ELOF1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcription elongation factor implicated in the maintenance
CC       of proper chromatin structure in actively transcribed regions.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       P60002; Q49AR2: C5orf22; NbExp=6; IntAct=EBI-714648, EBI-746224;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ELOF1 family. {ECO:0000305}.
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DR   EMBL; BC007516; AAH07516.1; -; mRNA.
DR   CCDS; CCDS12264.1; -.
DR   CCDS; CCDS86703.1; -.
DR   RefSeq; NP_115753.1; NM_032377.3.
DR   RefSeq; XP_016882847.1; XM_017027358.1.
DR   RefSeq; XP_016882848.1; XM_017027359.1.
DR   AlphaFoldDB; P60002; -.
DR   SMR; P60002; -.
DR   BioGRID; 124061; 26.
DR   IntAct; P60002; 7.
DR   MINT; P60002; -.
DR   STRING; 9606.ENSP00000252445; -.
DR   iPTMnet; P60002; -.
DR   PhosphoSitePlus; P60002; -.
DR   BioMuta; ELOF1; -.
DR   DMDM; 38372864; -.
DR   EPD; P60002; -.
DR   jPOST; P60002; -.
DR   MassIVE; P60002; -.
DR   MaxQB; P60002; -.
DR   PaxDb; P60002; -.
DR   PeptideAtlas; P60002; -.
DR   PRIDE; P60002; -.
DR   ProteomicsDB; 57177; -.
DR   Antibodypedia; 13205; 88 antibodies from 23 providers.
DR   DNASU; 84337; -.
DR   Ensembl; ENST00000252445.7; ENSP00000252445.3; ENSG00000130165.10.
DR   Ensembl; ENST00000586120.5; ENSP00000467914.1; ENSG00000130165.10.
DR   Ensembl; ENST00000590700.5; ENSP00000467264.1; ENSG00000130165.10.
DR   GeneID; 84337; -.
DR   KEGG; hsa:84337; -.
DR   MANE-Select; ENST00000252445.8; ENSP00000252445.3; NM_032377.4; NP_115753.1.
DR   UCSC; uc002mse.1; human.
DR   CTD; 84337; -.
DR   DisGeNET; 84337; -.
DR   GeneCards; ELOF1; -.
DR   HGNC; HGNC:28691; ELOF1.
DR   HPA; ENSG00000130165; Low tissue specificity.
DR   MIM; 619818; gene.
DR   neXtProt; NX_P60002; -.
DR   OpenTargets; ENSG00000130165; -.
DR   PharmGKB; PA142671911; -.
DR   VEuPathDB; HostDB:ENSG00000130165; -.
DR   eggNOG; KOG3214; Eukaryota.
DR   GeneTree; ENSGT00390000000053; -.
DR   HOGENOM; CLU_105983_2_0_1; -.
DR   InParanoid; P60002; -.
DR   OMA; ISCRVCS; -.
DR   PhylomeDB; P60002; -.
DR   TreeFam; TF313731; -.
DR   PathwayCommons; P60002; -.
DR   SignaLink; P60002; -.
DR   BioGRID-ORCS; 84337; 249 hits in 1088 CRISPR screens.
DR   ChiTaRS; ELOF1; human.
DR   GenomeRNAi; 84337; -.
DR   Pharos; P60002; Tbio.
DR   PRO; PR:P60002; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; P60002; protein.
DR   Bgee; ENSG00000130165; Expressed in left testis and 179 other tissues.
DR   ExpressionAtlas; P60002; baseline and differential.
DR   Genevisible; P60002; HS.
DR   GO; GO:0008023; C:transcription elongation factor complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 2.20.25.190; -; 1.
DR   InterPro; IPR007808; Elf1.
DR   InterPro; IPR038567; T_Elf1_sf.
DR   PANTHER; PTHR20934; PTHR20934; 1.
DR   Pfam; PF05129; Elf1; 1.
PE   1: Evidence at protein level;
KW   Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..83
FT                   /note="Transcription elongation factor 1 homolog"
FT                   /id="PRO_0000120941"
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P60003"
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P60003"
FT   BINDING         50
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P60003"
FT   BINDING         53
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P60003"
SQ   SEQUENCE   83 AA;  9462 MW;  77F11EFBEC72AC6F CRC64;
     MGRRKSKRKP PPKKKMTGTL ETQFTCPFCN HEKSCDVKMD RARNTGVISC TVCLEEFQTP
     ITYLSEPVDV YSDWIDACEA ANQ