ID   ELOF1_MOUSE             Reviewed;          83 AA.
AC   P60003; Q8R1J7; Q96II4;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2003, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Transcription elongation factor 1 homolog;
GN   Name=Elof1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Colon, Liver, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   STRUCTURE BY NMR OF 8-79 IN COMPLEX WITH ZINC, AND ZINC-BINDING SITES.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of RSGI RUH-025, a DUF701 domain from mouse cDNA.";
RL   Submitted (MAY-2004) to the PDB data bank.
CC   -!- FUNCTION: Transcription elongation factor implicated in the maintenance
CC       of proper chromatin structure in actively transcribed regions.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ELOF1 family. {ECO:0000305}.
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DR   EMBL; BC019870; AAH19870.3; -; mRNA.
DR   EMBL; BC024488; AAH24488.3; -; mRNA.
DR   EMBL; BC056225; AAH56225.1; -; mRNA.
DR   CCDS; CCDS40559.1; -.
DR   RefSeq; NP_740747.1; NM_170777.3.
DR   RefSeq; XP_017168995.1; XM_017313506.1.
DR   RefSeq; XP_017168996.1; XM_017313507.1.
DR   RefSeq; XP_017168997.1; XM_017313508.1.
DR   PDB; 1WII; NMR; -; A=8-79.
DR   PDBsum; 1WII; -.
DR   AlphaFoldDB; P60003; -.
DR   SMR; P60003; -.
DR   BioGRID; 211234; 1.
DR   STRING; 10090.ENSMUSP00000128173; -.
DR   PhosphoSitePlus; P60003; -.
DR   EPD; P60003; -.
DR   PaxDb; P60003; -.
DR   PeptideAtlas; P60003; -.
DR   PRIDE; P60003; -.
DR   ProteomicsDB; 275453; -.
DR   Antibodypedia; 13205; 88 antibodies from 23 providers.
DR   DNASU; 66126; -.
DR   Ensembl; ENSMUST00000013966; ENSMUSP00000013966; ENSMUSG00000013822.
DR   Ensembl; ENSMUST00000166335; ENSMUSP00000128173; ENSMUSG00000013822.
DR   Ensembl; ENSMUST00000213233; ENSMUSP00000150169; ENSMUSG00000013822.
DR   Ensembl; ENSMUST00000214394; ENSMUSP00000150536; ENSMUSG00000013822.
DR   Ensembl; ENSMUST00000216837; ENSMUSP00000149885; ENSMUSG00000013822.
DR   GeneID; 66126; -.
DR   KEGG; mmu:66126; -.
DR   UCSC; uc009onw.1; mouse.
DR   CTD; 84337; -.
DR   MGI; MGI:1913376; Elof1.
DR   VEuPathDB; HostDB:ENSMUSG00000013822; -.
DR   eggNOG; KOG3214; Eukaryota.
DR   GeneTree; ENSGT00390000000053; -.
DR   HOGENOM; CLU_105983_2_0_1; -.
DR   InParanoid; P60003; -.
DR   OMA; ISCRVCS; -.
DR   OrthoDB; 1630132at2759; -.
DR   PhylomeDB; P60003; -.
DR   TreeFam; TF313731; -.
DR   BioGRID-ORCS; 66126; 19 hits in 71 CRISPR screens.
DR   ChiTaRS; Elof1; mouse.
DR   EvolutionaryTrace; P60003; -.
DR   PRO; PR:P60003; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; P60003; protein.
DR   Bgee; ENSMUSG00000013822; Expressed in spermatid and 64 other tissues.
DR   ExpressionAtlas; P60003; baseline and differential.
DR   Genevisible; P60003; MM.
DR   GO; GO:0008023; C:transcription elongation factor complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 2.20.25.190; -; 1.
DR   InterPro; IPR007808; Elf1.
DR   InterPro; IPR038567; T_Elf1_sf.
DR   PANTHER; PTHR20934; PTHR20934; 1.
DR   Pfam; PF05129; Elf1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..83
FT                   /note="Transcription elongation factor 1 homolog"
FT                   /id="PRO_0000120942"
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007744|PDB:1WII"
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007744|PDB:1WII"
FT   BINDING         50
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007744|PDB:1WII"
FT   BINDING         53
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007744|PDB:1WII"
FT   TURN            27..29
FT                   /evidence="ECO:0007829|PDB:1WII"
FT   STRAND          35..40
FT                   /evidence="ECO:0007829|PDB:1WII"
FT   TURN            41..44
FT                   /evidence="ECO:0007829|PDB:1WII"
FT   STRAND          45..53
FT                   /evidence="ECO:0007829|PDB:1WII"
FT   STRAND          56..60
FT                   /evidence="ECO:0007829|PDB:1WII"
FT   HELIX           69..79
FT                   /evidence="ECO:0007829|PDB:1WII"
SQ   SEQUENCE   83 AA;  9462 MW;  77F11EFBEC72AC6F CRC64;
     MGRRKSKRKP PPKKKMTGTL ETQFTCPFCN HEKSCDVKMD RARNTGVISC TVCLEEFQTP
     ITYLSEPVDV YSDWIDACEA ANQ