ELOF_DROSI
ID ELOF_DROSI Reviewed; 263 AA.
AC B4QVX4;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Elongation of very long chain fatty acids protein F {ECO:0000250|UniProtKB:Q9VH58};
DE EC=2.3.1.199 {ECO:0000255|RuleBase:RU361115};
DE AltName: Full=Very-long-chain 3-oxoacyl-CoA synthase {ECO:0000255|RuleBase:RU361115};
GN ORFNames=GD18654;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000312|Proteomes:UP000000304};
RN [1] {ECO:0000312|Proteomes:UP000000304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=17360514; DOI=10.1073/pnas.0608142104;
RA Chertemps T., Duportets L., Labeur C., Ueda R., Takahashi K., Saigo K.,
RA Wicker-Thomas C.;
RT "A female-biased expressed elongase involved in long-chain hydrocarbon
RT biosynthesis and courtship behavior in Drosophila melanogaster.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:4273-4278(2007).
CC -!- FUNCTION: Condensing enzyme that elongates saturated and
CC monounsaturated very long chain fatty acids, to yield products up to 30
CC carbons in length. {ECO:0000250|UniProtKB:Q9VH58}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC EC=2.3.1.199; Evidence={ECO:0000255|RuleBase:RU361115};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9VH58}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: No expression in adults.
CC {ECO:0000269|PubMed:17360514}.
CC -!- MISCELLANEOUS: In D.melanogaster, functions in the elongation of long-
CC chain C27 and C29 hydrocarbons. However, no expression is detected in
CC D.simulans adult females or males which synthesize only short-chain C23
CC and C25 hydrocarbons. {ECO:0000303|PubMed:17360514}.
CC -!- SIMILARITY: Belongs to the ELO family. {ECO:0000305}.
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DR EMBL; CM000364; EDX13554.1; -; Genomic_DNA.
DR AlphaFoldDB; B4QVX4; -.
DR SMR; B4QVX4; -.
DR STRING; 7240.B4QVX4; -.
DR HOGENOM; CLU_048483_0_2_1; -.
DR OMA; VAFPQCL; -.
DR PhylomeDB; B4QVX4; -.
DR Proteomes; UP000000304; Chromosome 3r.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009922; F:fatty acid elongase activity; IEA:EnsemblMetazoa.
DR GO; GO:0102756; F:very-long-chain 3-ketoacyl-CoA synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0007619; P:courtship behavior; IEA:EnsemblMetazoa.
DR GO; GO:0042810; P:pheromone metabolic process; IEA:EnsemblMetazoa.
DR GO; GO:0042761; P:very long-chain fatty acid biosynthetic process; IEA:EnsemblMetazoa.
DR InterPro; IPR030457; ELO_CS.
DR InterPro; IPR002076; ELO_fam.
DR PANTHER; PTHR11157; PTHR11157; 1.
DR Pfam; PF01151; ELO; 1.
DR PROSITE; PS01188; ELO; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..263
FT /note="Elongation of very long chain fatty acids protein F"
FT /id="PRO_0000439076"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 263 AA; 30607 MW; BFD2E440F07626EF CRC64;
MFAPIDPVKI PVFSDPWITM ATLSGYLLFV LKLGPKIMEN RKPFHLSGVI RVYNIFQILY
NGLILVLGVH FLFVLKAYQI SCIVSLPMDH KYKDRERLIC ILYMLNKFVD LVETIFFVLR
KKDRQISFLH VFHHFAMAFL GYLYYYFHGY GGVAFPQCLC LLNTAVHVIM YAYYYLSSIS
QELQRSLWWK KYITIAQLVQ FGIILLHCTI TLAQPDCAVN RPLTYGCGSL SAFFAVIFSQ
FYYHNYIKPG EKSSKQSAIH KNL
