ELOV4_MACFA
ID ELOV4_MACFA Reviewed; 314 AA.
AC Q95K73;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Elongation of very long chain fatty acids protein 4 {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000305};
DE EC=2.3.1.199 {ECO:0000255|HAMAP-Rule:MF_03204};
DE AltName: Full=3-keto acyl-CoA synthase ELOVL4 {ECO:0000255|HAMAP-Rule:MF_03204};
DE AltName: Full=ELOVL fatty acid elongase 4 {ECO:0000255|HAMAP-Rule:MF_03204};
DE Short=ELOVL FA elongase 4 {ECO:0000255|HAMAP-Rule:MF_03204};
DE AltName: Full=Very long chain 3-ketoacyl-CoA synthase 4 {ECO:0000255|HAMAP-Rule:MF_03204};
DE AltName: Full=Very long chain 3-oxoacyl-CoA synthase 4 {ECO:0000255|HAMAP-Rule:MF_03204};
GN Name=ELOVL4 {ECO:0000255|HAMAP-Rule:MF_03204}; ORFNames=QtrA-14469;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12806887; DOI=10.1538/expanim.52.129;
RA Umeda S., Ayyagari R., Suzuki M.T., Ono F., Iwata F., Fujiki K., Kanai A.,
RA Takada Y., Yoshikawa Y., Tanaka Y., Iwata T.;
RT "Molecular cloning of ELOVL4 gene from cynomolgus monkey (Macaca
RT fascicularis).";
RL Exp. Anim. 52:129-135(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Temporal cortex;
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the first and rate-limiting reaction of the four
CC reactions that constitute the long-chain fatty acids elongation cycle.
CC This endoplasmic reticulum-bound enzymatic process allows the addition
CC of 2 carbons to the chain of long- and very long-chain fatty acids
CC (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of
CC very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty
CC acids that are involved in multiple biological processes as precursors
CC of membrane lipids and lipid mediators. May play a critical role in
CC early brain and skin development. {ECO:0000255|HAMAP-Rule:MF_03204}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC EC=2.3.1.199; Evidence={ECO:0000255|HAMAP-Rule:MF_03204};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32728;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + hexacosanoyl-CoA + malonyl-CoA = 3-oxooctacosanyol-CoA
CC + CO2 + CoA; Xref=Rhea:RHEA:36519, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:64868, ChEBI:CHEBI:73976;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36520;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + malonyl-CoA + octacosanoyl-CoA = 3-oxo-triacontanoyl-
CC CoA + CO2 + CoA; Xref=Rhea:RHEA:36807, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74141, ChEBI:CHEBI:74228;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36808;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + malonyl-CoA + triacontanoyl-CoA = 3-oxo-
CC dotriacontanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:43852,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:76386, ChEBI:CHEBI:83795;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43853;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA
CC + CO2 + CoA; Xref=Rhea:RHEA:36871, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74260, ChEBI:CHEBI:74261;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36872;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-
CC CoA = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 +
CC CoA; Xref=Rhea:RHEA:36943, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74298,
CC ChEBI:CHEBI:74304; Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36944;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA =
CC (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA;
CC Xref=Rhea:RHEA:36479, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:73856,
CC ChEBI:CHEBI:73857; Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36480;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-
CC CoA = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA;
CC Xref=Rhea:RHEA:36819, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74229,
CC ChEBI:CHEBI:74230; Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36820;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-
CC CoA = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 +
CC CoA; Xref=Rhea:RHEA:36843, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74233,
CC ChEBI:CHEBI:74246; Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36844;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA +
CC CO2 + CoA; Xref=Rhea:RHEA:36851, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74247, ChEBI:CHEBI:74254;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36852;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-
CC CoA + CO2 + CoA; Xref=Rhea:RHEA:36859, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74249, ChEBI:CHEBI:74259;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36860;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA
CC + CO2 + CoA; Xref=Rhea:RHEA:36875, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74262, ChEBI:CHEBI:74263;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36876;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA
CC = (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA;
CC Xref=Rhea:RHEA:36907, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74282,
CC ChEBI:CHEBI:74283; Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36908;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA
CC = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA;
CC Xref=Rhea:RHEA:36911, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74285,
CC ChEBI:CHEBI:74286; Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36912;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA
CC = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA;
CC Xref=Rhea:RHEA:36915, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74287,
CC ChEBI:CHEBI:74288; Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36916;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-
CC CoA = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 +
CC CoA; Xref=Rhea:RHEA:36919, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74289,
CC ChEBI:CHEBI:74290; Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36920;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA +
CC CO2 + CoA; Xref=Rhea:RHEA:36923, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74291, ChEBI:CHEBI:74292;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36924;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA +
CC CO2 + CoA; Xref=Rhea:RHEA:36927, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74293, ChEBI:CHEBI:74294;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36928;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA +
CC CO2 + CoA; Xref=Rhea:RHEA:36947, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74086, ChEBI:CHEBI:74305;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36948;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA +
CC CO2 + CoA; Xref=Rhea:RHEA:36963, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74306, ChEBI:CHEBI:74311;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36964;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA
CC + CO2 + CoA; Xref=Rhea:RHEA:36967, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74312, ChEBI:CHEBI:74313;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36968;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-
CC CoA + CO2 + CoA; Xref=Rhea:RHEA:36979, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74315, ChEBI:CHEBI:74316;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36980;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-
CC tetratriacontahexaenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36983,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:74317, ChEBI:CHEBI:74318;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36984;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) +
CC malonyl-CoA = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-
CC CoA + CO2 + CoA; Xref=Rhea:RHEA:36995, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384,
CC ChEBI:CHEBI:74319, ChEBI:CHEBI:74320;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36996;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-
CC CoA = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA;
CC Xref=Rhea:RHEA:37243, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74083,
CC ChEBI:CHEBI:74663; Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37244;
CC Evidence={ECO:0000250|UniProtKB:Q9EQC4};
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-
CC Rule:MF_03204}.
CC -!- SUBUNIT: Oligomer. {ECO:0000255|HAMAP-Rule:MF_03204}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000255|HAMAP-Rule:MF_03204}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_03204}.
CC -!- TISSUE SPECIFICITY: Expressed mainly in retina. Also expressed in skin
CC and thymus. {ECO:0000269|PubMed:12806887}.
CC -!- DOMAIN: The C-terminal di-lysine motif confers endoplasmic reticulum
CC localization. {ECO:0000255|HAMAP-Rule:MF_03204}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9EQC4}.
CC -!- SIMILARITY: Belongs to the ELO family. ELOVL4 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03204}.
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DR EMBL; AF461182; AAO15594.1; -; mRNA.
DR EMBL; AF461187; AAO15601.1; -; Genomic_DNA.
DR EMBL; AF461183; AAO15601.1; JOINED; Genomic_DNA.
DR EMBL; AF461184; AAO15601.1; JOINED; Genomic_DNA.
DR EMBL; AF461185; AAO15601.1; JOINED; Genomic_DNA.
DR EMBL; AF461186; AAO15601.1; JOINED; Genomic_DNA.
DR EMBL; AB063100; BAB60806.1; -; mRNA.
DR RefSeq; NP_001270132.1; NM_001283203.1.
DR AlphaFoldDB; Q95K73; -.
DR SMR; Q95K73; -.
DR STRING; 9541.XP_005552550.1; -.
DR Ensembl; ENSMFAT00000025305; ENSMFAP00000006619; ENSMFAG00000036147.
DR GeneID; 102138130; -.
DR CTD; 6785; -.
DR VEuPathDB; HostDB:ENSMFAG00000036147; -.
DR eggNOG; KOG3071; Eukaryota.
DR GeneTree; ENSGT01050000244838; -.
DR OMA; AACGPKF; -.
DR OrthoDB; 1094172at2759; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000233100; Chromosome 4.
DR Bgee; ENSMFAG00000036147; Expressed in thymus and 5 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0009922; F:fatty acid elongase activity; ISS:UniProtKB.
DR GO; GO:0102756; F:very-long-chain 3-ketoacyl-CoA synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0034626; P:fatty acid elongation, polyunsaturated fatty acid; ISS:UniProtKB.
DR GO; GO:0019367; P:fatty acid elongation, saturated fatty acid; ISS:UniProtKB.
DR GO; GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0042761; P:very long-chain fatty acid biosynthetic process; ISS:UniProtKB.
DR HAMAP; MF_03204; VLCF_elongase_4; 1.
DR InterPro; IPR030457; ELO_CS.
DR InterPro; IPR002076; ELO_fam.
DR InterPro; IPR033678; ELOVL4.
DR PANTHER; PTHR11157; PTHR11157; 1.
DR Pfam; PF01151; ELO; 1.
DR PROSITE; PS01188; ELO; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism;
KW Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Elongation of very long chain fatty acids protein 4"
FT /id="PRO_0000207543"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03204"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03204"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03204"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03204"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03204"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03204"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03204"
FT REGION 274..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 310..314
FT /note="Di-lysine motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03204"
FT COMPBIAS 282..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03204"
SQ SEQUENCE 314 AA; 36812 MW; 560FE00C91D96766 CRC64;
MGLLDSEPGS VLNVVSTALN DTVEFYRWTW SIADKRVENW PLMQSPWPTL SISTLYLLFV
WLGPKWMKDR EPFQMRLVLI IYNFGMVLLN FFIFRELFMG SYNAGYSYIC QSVDYSNNVN
EVRIAAALWW YFVSKGVEYL DTVFFILRKK NNQVSFLHVY HHCTMFTLWW IGIKWVAGGQ
AFFGAQMNSF IHVIMYSYYG LAAFGPWIQK YLWWKRYLTM LQLVQFHVTI GHTALSLYTD
CPFPKWMHWA LIAYAISFIF LFLNFYIRTY KEPKKPKTGK TAMNGISANG VSKSEKQLVI
ENGKKQKNGK AKGD
