ELP2_RAT
ID ELP2_RAT Reviewed; 821 AA.
AC Q496Z0; Q562B6;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Elongator complex protein 2;
DE Short=ELP2;
DE AltName: Full=SHINC-2;
DE AltName: Full=STAT3-interacting protein 1;
DE Short=StIP1;
GN Name=Elp2; Synonyms=Statip1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the elongator complex which is required for
CC multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC (5-carbamoylmethyl uridine). The elongator complex catalyzes the
CC formation of carboxymethyluridine in the wobble base at position 34 in
CC tRNAs. {ECO:0000250|UniProtKB:Q6IA86}.
CC -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC biosynthesis. {ECO:0000250|UniProtKB:Q6IA86}.
CC -!- SUBUNIT: Component of the elongator complex which consists of ELP1,
CC ELP2, ELP3, ELP4, ELP5 and ELP6. Interacts with STAT3 and JAKs (By
CC similarity). {ECO:0000250|UniProtKB:Q6IA86,
CC ECO:0000250|UniProtKB:Q91WG4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6IA86}. Nucleus
CC {ECO:0000250|UniProtKB:Q6IA86}.
CC -!- DOMAIN: Folds into a two seven-bladed beta-propeller structure which is
CC required for elongator complex assembly.
CC {ECO:0000250|UniProtKB:P42935}.
CC -!- SIMILARITY: Belongs to the WD repeat ELP2 family. {ECO:0000305}.
CC -!- CAUTION: The elongator complex was originally thought to play a role in
CC transcription elongation. However, it is no longer thought to play a
CC direct role in this process and its primary function is thought to be
CC in tRNA modification. {ECO:0000250|UniProtKB:Q6IA86}.
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DR EMBL; BC092606; AAH92606.1; -; mRNA.
DR EMBL; BC100661; AAI00662.1; -; mRNA.
DR RefSeq; NP_001029317.1; NM_001034145.1.
DR AlphaFoldDB; Q496Z0; -.
DR SMR; Q496Z0; -.
DR STRING; 10116.ENSRNOP00000020601; -.
DR iPTMnet; Q496Z0; -.
DR PhosphoSitePlus; Q496Z0; -.
DR jPOST; Q496Z0; -.
DR PaxDb; Q496Z0; -.
DR PRIDE; Q496Z0; -.
DR Ensembl; ENSRNOT00000020601; ENSRNOP00000020601; ENSRNOG00000015301.
DR GeneID; 307545; -.
DR KEGG; rno:307545; -.
DR UCSC; RGD:1306419; rat.
DR CTD; 55250; -.
DR RGD; 1306419; Elp2.
DR eggNOG; KOG1063; Eukaryota.
DR GeneTree; ENSGT00390000000916; -.
DR HOGENOM; CLU_006430_1_0_1; -.
DR InParanoid; Q496Z0; -.
DR OMA; EHTKRVN; -.
DR OrthoDB; 461632at2759; -.
DR PhylomeDB; Q496Z0; -.
DR TreeFam; TF105985; -.
DR UniPathway; UPA00988; -.
DR PRO; PR:Q496Z0; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000015301; Expressed in skeletal muscle tissue and 20 other tissues.
DR Genevisible; Q496Z0; RN.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0033588; C:elongator holoenzyme complex; ISS:UniProtKB.
DR GO; GO:0008023; C:transcription elongation factor complex; ISO:RGD.
DR GO; GO:0019901; F:protein kinase binding; ISO:RGD.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IEA:Ensembl.
DR GO; GO:0046425; P:regulation of receptor signaling pathway via JAK-STAT; ISO:RGD.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 5.
DR InterPro; IPR037289; Elp2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR44111; PTHR44111; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF50978; SSF50978; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; tRNA processing; WD repeat.
FT CHAIN 1..821
FT /note="Elongator complex protein 2"
FT /id="PRO_0000051243"
FT REPEAT 56..100
FT /note="WD 1"
FT REPEAT 105..152
FT /note="WD 2"
FT REPEAT 160..200
FT /note="WD 3"
FT REPEAT 205..246
FT /note="WD 4"
FT REPEAT 280..328
FT /note="WD 5"
FT REPEAT 338..377
FT /note="WD 6"
FT REPEAT 385..424
FT /note="WD 7"
FT REPEAT 435..473
FT /note="WD 8"
FT REPEAT 563..607
FT /note="WD 9"
FT REPEAT 610..649
FT /note="WD 10"
FT REPEAT 665..704
FT /note="WD 11"
FT REPEAT 716..760
FT /note="WD 12"
FT REPEAT 773..821
FT /note="WD 13"
SQ SEQUENCE 821 AA; 91746 MW; EF93996212B557CE CRC64;
MVSSVLEVSY VFCCPNRARG ALSWNSGPGG LLAFGTSCSV VLYDPQKKVV ITNLNGHTAR
VNCLHWIRTE DGSPSTELVS GASDNRVIHW ELENNQVLKS VRLQGHEGPV YAVHGIYQSG
PSDGEQHALI ASAASDSTVR LWSKKGSEVK CLQILKFGDG FVLTVCLSTL PDTDAPVLAC
GDDGGRIHLF VQQDDWFQKM LSLCGHEDWI RGVEWATFGR DLFLASCSQD CLIRIWRLYM
KPTSLETEDG SIRLKENTFT IKDGGVSTTV AVILETVLAG HENWVNAIHW QPSFYKDGVL
HQPVRLLSAS MDKTMILWAP DEESGVWLEQ VRVGEVGGNT LGFYGCQFGE NGSMIIAHAF
HGAMHLWKQS TVNPRQWAPE IVISGHFDGV QDLIWDPEGE FIITTSTDQT TRLFAPWKKK
NQSQVTWHEI ARPQIHGYNL KCLAMIDRFQ FVSGADEKVL RVFSAPRNFV ENFSVISRQS
LSHMLYDEDN DLPEGATVPA LGLSNKAVFE GDMTYLTSEE EELLSPAFGY PQVIFQPAVL
SEPPTEDHLL QNTLWPEVQK LYGHGYEIFC VTCNNSKTLL ASACKAAQKE HAAIILWSTT
SWKQVQSLAY HTLTVTQMAF SPDDKFLLAV SRDRTWSLWK RQDVTSAEFD PFFSLFAFTN
KITSVHSRII WSCDWSPDSK YFFTGSRDKK VVVWGECNSS YNPMEHPINP CSSILDVGSC
VTAVSVCPVL NPAQRYIVAV GLESGKICIY SWSKTNQETK DWTSCVETTP SQSHTLGIRR
LCWKSCSGST EQSEEGTEWL DFASCGEDHT VKIYRVNRCA L
