ID   ELP4_CAEEL              Reviewed;         334 AA.
AC   Q18195;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Elongator complex protein 4;
DE            Short=ELP4;
GN   Name=elpc-4; ORFNames=C26B2.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the elongator complex which is required for
CC       multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC       uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC       (5-carbamoylmethyl uridine). The elongator complex catalyzes the
CC       formation of carboxymethyluridine in the wobble base at position 34 in
CC       tRNAs. {ECO:0000250|UniProtKB:Q96EB1}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000250|UniProtKB:Q96EB1}.
CC   -!- SUBUNIT: Component of the elongator complex.
CC       {ECO:0000250|UniProtKB:Q96EB1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96EB1}. Nucleus
CC       {ECO:0000250|UniProtKB:Q96EB1}.
CC   -!- SIMILARITY: Belongs to the ELP4 family. {ECO:0000305}.
CC   -!- CAUTION: The elongator complex was originally thought to play a role in
CC       transcription elongation. However, it is no longer thought to play a
CC       direct role in this process and its primary function is thought to be
CC       in tRNA modification. {ECO:0000250|UniProtKB:Q96EB1}.
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DR   EMBL; FO080616; CCD65198.1; -; Genomic_DNA.
DR   PIR; T34124; T34124.
DR   RefSeq; NP_501343.1; NM_068942.5.
DR   AlphaFoldDB; Q18195; -.
DR   SMR; Q18195; -.
DR   BioGRID; 47768; 19.
DR   DIP; DIP-26243N; -.
DR   IntAct; Q18195; 3.
DR   STRING; 6239.C26B2.6; -.
DR   EPD; Q18195; -.
DR   PaxDb; Q18195; -.
DR   PeptideAtlas; Q18195; -.
DR   PRIDE; Q18195; -.
DR   EnsemblMetazoa; C26B2.6.1; C26B2.6.1; WBGene00016128.
DR   GeneID; 182929; -.
DR   UCSC; C26B2.6; c. elegans.
DR   CTD; 182929; -.
DR   WormBase; C26B2.6; CE04092; WBGene00016128; elpc-4.
DR   eggNOG; KOG3949; Eukaryota.
DR   GeneTree; ENSGT00390000001443; -.
DR   HOGENOM; CLU_031345_3_1_1; -.
DR   InParanoid; Q18195; -.
DR   OMA; THNPPVD; -.
DR   OrthoDB; 973442at2759; -.
DR   PhylomeDB; Q18195; -.
DR   SignaLink; Q18195; -.
DR   UniPathway; UPA00988; -.
DR   PRO; PR:Q18195; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00016128; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0033588; C:elongator holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0008023; C:transcription elongation factor complex; ISS:UniProtKB.
DR   GO; GO:0008607; F:phosphorylase kinase regulator activity; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008728; Elongator_complex_protein_4.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12896; PTHR12896; 1.
DR   Pfam; PF05625; PAXNEB; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; tRNA processing.
FT   CHAIN           1..334
FT                   /note="Elongator complex protein 4"
FT                   /id="PRO_0000284009"
SQ   SEQUENCE   334 AA;  37632 MW;  C9CC5643E6CABF1E CRC64;
     MLNVGDSVQI AGCSTKKRLL ETSSGCDSFD TLIGGALVNS SIVLIDEYRS RCYGSYLIRS
     FLAEGLHHGH RCFIADPTED PKEINLIPSR RTSTDMQNQE IPNSLPAENE NSMKIAWRYG
     NVKQVSSSLG PLSNENQYDF TKHVENPNVD VYAEKVFTLK GIYETLCQIV KENEAHTKSG
     GRGGPKKNLL RVVLKNIDME ICEDYKFLGR FLCCLRSLAR SSYMIVYITA NSFRVPKPTW
     RILESAADTH IQLMPFDENE KKMFKHLGTA HGYFHLKSLP RLMSVGTHTP PILDLIFEAS
     SRKGFQIRVM HLPPAFDEPA PGHQNTPSCQ NIDF