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ELP5_DANRE
ID   ELP5_DANRE              Reviewed;         296 AA.
AC   A1A5V9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Elongator complex protein 5;
DE   AltName: Full=Dermal papilla-derived protein 6 homolog;
DE   AltName: Full=Retinoic acid-induced protein 12;
GN   Name=elp5; Synonyms=derp6, Rai12; ORFNames=zgc:158278, zgc:158285;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the elongator complex which is required for
CC       multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC       uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC       (5-carbamoylmethyl uridine) (By similarity). The elongator complex
CC       catalyzes the formation of carboxymethyluridine in the wobble base at
CC       position 34 in tRNAs (By similarity). {ECO:0000250|UniProtKB:Q8TE02}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000250|UniProtKB:Q8TE02}.
CC   -!- SUBUNIT: Component of the elongator complex.
CC       {ECO:0000250|UniProtKB:Q8TE02}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TE02}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8TE02}.
CC   -!- SIMILARITY: Belongs to the ELP5 family. {ECO:0000305}.
CC   -!- CAUTION: The elongator complex was originally thought to play a role in
CC       transcription elongation. However, it is no longer thought to play a
CC       direct role in this process and its primary function is thought to be
CC       in tRNA modification. {ECO:0000250|UniProtKB:Q8TE02}.
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DR   EMBL; BC128832; AAI28833.1; -; mRNA.
DR   EMBL; BC128833; AAI28834.1; -; mRNA.
DR   RefSeq; NP_001073536.1; NM_001080067.2.
DR   AlphaFoldDB; A1A5V9; -.
DR   SMR; A1A5V9; -.
DR   STRING; 7955.ENSDARP00000088643; -.
DR   PaxDb; A1A5V9; -.
DR   PeptideAtlas; A1A5V9; -.
DR   PRIDE; A1A5V9; -.
DR   GeneID; 790921; -.
DR   KEGG; dre:790921; -.
DR   CTD; 23587; -.
DR   ZFIN; ZDB-GENE-061215-33; elp5.
DR   eggNOG; ENOG502QQ2R; Eukaryota.
DR   InParanoid; A1A5V9; -.
DR   OrthoDB; 805928at2759; -.
DR   UniPathway; UPA00988; -.
DR   PRO; PR:A1A5V9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0033588; C:elongator holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0006400; P:tRNA modification; IBA:GO_Central.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR019519; Elp5.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR15641; PTHR15641; 1.
DR   Pfam; PF10483; Elong_Iki1; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; tRNA processing.
FT   CHAIN           1..296
FT                   /note="Elongator complex protein 5"
FT                   /id="PRO_0000280820"
FT   REGION          203..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..296
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   296 AA;  32739 MW;  092D3BFDB2ACFCA0 CRC64;
     MLLEVLQAAE AGGFILIQDS VQCCGRGILR CCINAALKRD EDVHVLGFES PETEVCAGLD
     SSFAQKLHFH KGFPDPLGWR GKSSFTVQQF TSQHITQLIR DSQPAKASVL VVDSLSLVLR
     HHDPVIVCQS LQELRKGGVV KTIIGLLHSD LHLQGIVGIV CHLASTVISV APTNNERHAV
     ATTTRRTKSG KVMQEEEYFS VSEDATLSVQ SKPRQHDRVE KEQDSAEVDP ASNLTFNLRL
     SEEERRAKEK VALPFVFSQE KKSALLRPTP GSGRIMYEPD ANDDFDEEDP DDDLDV
 
 
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