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ELP5_RAT
ID   ELP5_RAT                Reviewed;         318 AA.
AC   Q6IUP3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Elongator complex protein 5;
DE   AltName: Full=Dermal papilla-derived protein 6 homolog;
DE   AltName: Full=Retinoic acid-induced protein 12;
GN   Name=Elp5; Synonyms=Derp6, Rai12;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yuan J., Shan Y.X.;
RT   "Cloning and characterization of a novel rat DERP6 gene.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the elongator complex which is required for
CC       multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC       uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC       (5-carbamoylmethyl uridine) (By similarity). The elongator complex
CC       catalyzes the formation of carboxymethyluridine in the wobble base at
CC       position 34 in tRNAs (By similarity). Involved in cell migration (By
CC       similarity). {ECO:0000250|UniProtKB:Q8TE02,
CC       ECO:0000250|UniProtKB:Q99L85}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000250|UniProtKB:Q8TE02}.
CC   -!- SUBUNIT: Component of the elongator complex which consists of ELP1,
CC       ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for
CC       optimal binding of ELP3 to ELP4. {ECO:0000250|UniProtKB:Q8TE02}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TE02}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8TE02}.
CC   -!- PTM: Tyrosine-phosphorylated. {ECO:0000250|UniProtKB:Q8TE02}.
CC   -!- SIMILARITY: Belongs to the ELP5 family. {ECO:0000305}.
CC   -!- CAUTION: The elongator complex was originally thought to play a role in
CC       transcription elongation. However, it is no longer thought to play a
CC       direct role in this process and its primary function is thought to be
CC       in tRNA modification. {ECO:0000250|UniProtKB:Q8TE02}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-19 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; AY623900; AAT40590.1; -; mRNA.
DR   RefSeq; NP_001001718.1; NM_001001718.1.
DR   AlphaFoldDB; Q6IUP3; -.
DR   SMR; Q6IUP3; -.
DR   BioGRID; 252166; 1.
DR   STRING; 10116.ENSRNOP00000035345; -.
DR   PhosphoSitePlus; Q6IUP3; -.
DR   PaxDb; Q6IUP3; -.
DR   PeptideAtlas; Q6IUP3; -.
DR   PRIDE; Q6IUP3; -.
DR   GeneID; 287446; -.
DR   KEGG; rno:287446; -.
DR   UCSC; RGD:1303303; rat.
DR   CTD; 23587; -.
DR   RGD; 1303303; Elp5.
DR   eggNOG; ENOG502QQ2R; Eukaryota.
DR   HOGENOM; CLU_076374_0_0_1; -.
DR   InParanoid; Q6IUP3; -.
DR   UniPathway; UPA00988; -.
DR   PRO; PR:Q6IUP3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q6IUP3; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0033588; C:elongator holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0006400; P:tRNA modification; IBA:GO_Central.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR   InterPro; IPR019519; Elp5.
DR   PANTHER; PTHR15641; PTHR15641; 1.
DR   Pfam; PF10483; Elong_Iki1; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; tRNA processing.
FT   CHAIN           1..318
FT                   /note="Elongator complex protein 5"
FT                   /id="PRO_0000280819"
FT   MOD_RES         270
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TE02"
SQ   SEQUENCE   318 AA;  35490 MW;  39E9C43AA98CA7F4 CRC64;
     MPRLLSGDDI RRRPEASEML DSLLATGGLV LLRDSVEWEG RGLLKALIKK SALRGEQVHV
     LGCEVSEEEF REGLGSDVNS RLVYHDLFRD PLNWSQPGEA APEGPLKALR SMCRRTDRGS
     VTIALDSLSW LLCHIPCVTL CQALHALSQR NVDPGDNPLI EQVRVLGLLH EELHGPGPVG
     AVSSLAHTEV TLSGKMDQTS ASILCRRPQQ RATYQTWWFS ILPDFSLDLH EGLPLHSELH
     RDPHTTQVDP ASHLTFNLHL SKKEREAKDS LTLPFQFSSE KQQALLHPVP GQTTGRIFYE
     PDAFDDVDQE DPDDDLDI
 
 
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