ELP5_RAT
ID ELP5_RAT Reviewed; 318 AA.
AC Q6IUP3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Elongator complex protein 5;
DE AltName: Full=Dermal papilla-derived protein 6 homolog;
DE AltName: Full=Retinoic acid-induced protein 12;
GN Name=Elp5; Synonyms=Derp6, Rai12;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yuan J., Shan Y.X.;
RT "Cloning and characterization of a novel rat DERP6 gene.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the elongator complex which is required for
CC multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC (5-carbamoylmethyl uridine) (By similarity). The elongator complex
CC catalyzes the formation of carboxymethyluridine in the wobble base at
CC position 34 in tRNAs (By similarity). Involved in cell migration (By
CC similarity). {ECO:0000250|UniProtKB:Q8TE02,
CC ECO:0000250|UniProtKB:Q99L85}.
CC -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC biosynthesis. {ECO:0000250|UniProtKB:Q8TE02}.
CC -!- SUBUNIT: Component of the elongator complex which consists of ELP1,
CC ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for
CC optimal binding of ELP3 to ELP4. {ECO:0000250|UniProtKB:Q8TE02}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TE02}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8TE02}.
CC -!- PTM: Tyrosine-phosphorylated. {ECO:0000250|UniProtKB:Q8TE02}.
CC -!- SIMILARITY: Belongs to the ELP5 family. {ECO:0000305}.
CC -!- CAUTION: The elongator complex was originally thought to play a role in
CC transcription elongation. However, it is no longer thought to play a
CC direct role in this process and its primary function is thought to be
CC in tRNA modification. {ECO:0000250|UniProtKB:Q8TE02}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-19 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AY623900; AAT40590.1; -; mRNA.
DR RefSeq; NP_001001718.1; NM_001001718.1.
DR AlphaFoldDB; Q6IUP3; -.
DR SMR; Q6IUP3; -.
DR BioGRID; 252166; 1.
DR STRING; 10116.ENSRNOP00000035345; -.
DR PhosphoSitePlus; Q6IUP3; -.
DR PaxDb; Q6IUP3; -.
DR PeptideAtlas; Q6IUP3; -.
DR PRIDE; Q6IUP3; -.
DR GeneID; 287446; -.
DR KEGG; rno:287446; -.
DR UCSC; RGD:1303303; rat.
DR CTD; 23587; -.
DR RGD; 1303303; Elp5.
DR eggNOG; ENOG502QQ2R; Eukaryota.
DR HOGENOM; CLU_076374_0_0_1; -.
DR InParanoid; Q6IUP3; -.
DR UniPathway; UPA00988; -.
DR PRO; PR:Q6IUP3; -.
DR Proteomes; UP000002494; Unplaced.
DR Genevisible; Q6IUP3; RN.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0033588; C:elongator holoenzyme complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0006400; P:tRNA modification; IBA:GO_Central.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR InterPro; IPR019519; Elp5.
DR PANTHER; PTHR15641; PTHR15641; 1.
DR Pfam; PF10483; Elong_Iki1; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; tRNA processing.
FT CHAIN 1..318
FT /note="Elongator complex protein 5"
FT /id="PRO_0000280819"
FT MOD_RES 270
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TE02"
SQ SEQUENCE 318 AA; 35490 MW; 39E9C43AA98CA7F4 CRC64;
MPRLLSGDDI RRRPEASEML DSLLATGGLV LLRDSVEWEG RGLLKALIKK SALRGEQVHV
LGCEVSEEEF REGLGSDVNS RLVYHDLFRD PLNWSQPGEA APEGPLKALR SMCRRTDRGS
VTIALDSLSW LLCHIPCVTL CQALHALSQR NVDPGDNPLI EQVRVLGLLH EELHGPGPVG
AVSSLAHTEV TLSGKMDQTS ASILCRRPQQ RATYQTWWFS ILPDFSLDLH EGLPLHSELH
RDPHTTQVDP ASHLTFNLHL SKKEREAKDS LTLPFQFSSE KQQALLHPVP GQTTGRIFYE
PDAFDDVDQE DPDDDLDI