ID   ELP6_DANRE              Reviewed;         264 AA.
AC   Q0P424; A7MCM9; A8DZD8;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Elongator complex protein 6;
DE   AltName: Full=Protein TMEM103;
GN   Name=elp6; Synonyms=tmem103; ORFNames=si:dkey-77n11.4, zgc:153530;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo, and Intestine;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the elongator complex which is required for
CC       multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC       uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC       (5-carbamoylmethyl uridine) (By similarity). The elongator complex
CC       catalyzes formation of carboxymethyluridine in the wobble base at
CC       position 34 in tRNAs (By similarity). {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SUBUNIT: Component of the elongator complex.
CC       {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SIMILARITY: Belongs to the ELP6 family. {ECO:0000305}.
CC   -!- CAUTION: The elongator complex was originally thought to play a role in
CC       transcription elongation. However, it is no longer thought to play a
CC       direct role in this process and its primary function is thought to be
CC       in tRNA modification. {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP09601.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL929190; CAP09601.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC122319; AAI22320.1; -; mRNA.
DR   EMBL; BC152243; AAI52244.1; -; mRNA.
DR   RefSeq; NP_001096612.1; NM_001103142.1.
DR   AlphaFoldDB; Q0P424; -.
DR   SMR; Q0P424; -.
DR   STRING; 7955.ENSDARP00000079599; -.
DR   PaxDb; Q0P424; -.
DR   Ensembl; ENSDART00000085164; ENSDARP00000079599; ENSDARG00000115612.
DR   Ensembl; ENSDART00000193517; ENSDARP00000145763; ENSDARG00000060445.
DR   GeneID; 751679; -.
DR   KEGG; dre:751679; -.
DR   CTD; 54859; -.
DR   ZFIN; ZDB-GENE-060825-249; elp6.
DR   eggNOG; KOG4723; Eukaryota.
DR   GeneTree; ENSGT00390000011734; -.
DR   InParanoid; Q0P424; -.
DR   OMA; MFTELNS; -.
DR   OrthoDB; 1272502at2759; -.
DR   PhylomeDB; Q0P424; -.
DR   TreeFam; TF331346; -.
DR   UniPathway; UPA00988; -.
DR   PRO; PR:Q0P424; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000060445; Expressed in swim bladder and 20 other tissues.
DR   ExpressionAtlas; Q0P424; baseline.
DR   GO; GO:0033588; C:elongator holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018627; ELP6.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR16184; PTHR16184; 1.
DR   Pfam; PF09807; ELP6; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; tRNA processing.
FT   CHAIN           1..264
FT                   /note="Elongator complex protein 6"
FT                   /id="PRO_0000274362"
FT   CONFLICT        211
FT                   /note="E -> K (in Ref. 2; AAI22320)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   264 AA;  29240 MW;  E233B31C5748AEB1 CRC64;
     MFPELNSLLN ASPDTFKPGD FILLSDRQAD ASFLIHHYLS FYLRAGCKVC FLGLVQSFSH
     YSAVGQRLGV SLTQAREKGQ LVFLEGLKDS IGAILKEDTS EGTQALSYLR SPRAGLEGLF
     RFVESSLCQS GDDGPPVLII DDLSVLLSLG VSAGAILDFT LYCRATVCSE LQGNMVILVR
     CEEEDADDDE EGLNLLQRGL VHQCHLALHV EGLPTGYCRD IHGQMEVWWR QGENDAYNQR
     KIFQFKVHDK GASFFTRGTS RAVL