ID   ELP6_DICDI              Reviewed;         338 AA.
AC   Q9GPT6; Q55EG9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Elongator complex protein 6;
GN   Name=elp6; ORFNames=DDB_G0268624;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=11222756; DOI=10.1093/nar/29.5.1068;
RA   Rivero F., Dislich H., Gloeckner G., Noegel A.A.;
RT   "The Dictyostelium discoideum family of Rho-related proteins.";
RL   Nucleic Acids Res. 29:1068-1079(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the elongator complex which is required for
CC       multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC       uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC       (5-carbamoylmethyl uridine) (By similarity). The elongator complex
CC       catalyzes formation of carboxymethyluridine in the wobble base at
CC       position 34 in tRNAs (By similarity). {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SUBUNIT: Component of the elongator complex.
CC       {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SIMILARITY: Belongs to the ELP6 family. {ECO:0000305}.
CC   -!- CAUTION: The elongator complex was originally thought to play a role in
CC       transcription elongation. However, it is no longer thought to play a
CC       direct role in this process and its primary function is thought to be
CC       in tRNA modification. {ECO:0000250|UniProtKB:Q0PNE2}.
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DR   EMBL; AF310884; AAG45111.1; -; Genomic_DNA.
DR   EMBL; AAFI02000004; EAL72901.1; -; Genomic_DNA.
DR   RefSeq; XP_647051.1; XM_641959.1.
DR   AlphaFoldDB; Q9GPT6; -.
DR   STRING; 44689.DDB0231762; -.
DR   PaxDb; Q9GPT6; -.
DR   EnsemblProtists; EAL72901; EAL72901; DDB_G0268624.
DR   GeneID; 8616746; -.
DR   KEGG; ddi:DDB_G0268624; -.
DR   dictyBase; DDB_G0268624; -.
DR   eggNOG; KOG4723; Eukaryota.
DR   HOGENOM; CLU_082493_0_0_1; -.
DR   InParanoid; Q9GPT6; -.
DR   OMA; MFTELNS; -.
DR   PhylomeDB; Q9GPT6; -.
DR   UniPathway; UPA00988; -.
DR   PRO; PR:Q9GPT6; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0033588; C:elongator holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018627; ELP6.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR16184; PTHR16184; 1.
DR   Pfam; PF09807; ELP6; 1.
PE   3: Inferred from homology;
KW   Reference proteome; tRNA processing.
FT   CHAIN           1..338
FT                   /note="Elongator complex protein 6"
FT                   /id="PRO_0000330361"
SQ   SEQUENCE   338 AA;  38417 MW;  C3A62C89E6BF3B37 CRC64;
     MDLFSHLNWY SGDFMNEDGE PIKSIPSGKL ILVSDTLESE GSFLIHYFLQ SIFKATTSTN
     SSTNNNNSNN SGGVGGGACL LGLNQSLYNY FNVGRKLGYN LTTEYNKGNF TFINGLSTPY
     KWIIEQRLQQ LEDQGIDEEP QLDSISQGFN PFPTIHLIDN KNITSSSSSS SYSNSNNKNK
     NNNELKDILY KIYNEFINDH KKRVMNNNNN SKTLFIIDGL NLLESHYSTN PSGSNMDILN
     FLQYCHNYIK ENSTTCSMII LYHSDCDEDS KFFNLLQYES DLTINITGLK SGYSKDIDGQ
     LNFIQKDEKN NTFTRVNPIH YQALDNSIRF FSMGSRIQ